I was amazed that the thread concerning Plaqenil sort of spiraled out of control. I am as much to blame for starting the conflict as anyone as I could have been a little less sarcastic with sweden in my response to his challenge to me.
Anyway, Red, of course there are numerical guestimates for the ADR prevalence of all dugs. These may not be available to the layman, but of course the info. can be found in the pharmacy specific literature that pharmacists/researchers use. Tools of the trade, so to speak, not normally available to all (who would want it, except, as in this case, a clinician?)
Anyway,I've been a part of this group since the Yahoo days. I never told anyone that I was completing a PharmD Degree, unless I was asked. No one can say I've tried to toot my horn or brag or "talk down" to anyone.
My screen name isn't "PrryjonesPharmD"
The only thing thats ever bothered me is when folks get rude without cause. Then yes, I can get a little condescending at times because you know what? If one is going to rudely criticize or challenge me, as Bradley and sweden have done, then yes...I'm going to call them on it...because concerning the subject matter, as I have been studying this stuff for the last 5 years (program is 6 yrs in length), then I do consider myself an expert, relative to the them. Arrogant as that sounds, you guys would prob. feel the same way if you were completing your 6th and final year of school and a layman basically told you that you we full of sh1t.
Since Kelli posted on the last thread, I will use her as an example: I seem to recall that Kelli is a designer. Ok...well then she is an expert in design relative to me. So, for me to arrogantly and rudely challenge her on some design principle that I know nothing about, this would prob. insult her and she would naturally want to know why I feel like I do. She would basically respond with, "Ok...you think I'm full of crap..so then show me what you've got". I can judge her proficiency as a designer no more than Bradley can arrogantly evaluate my proficiency as a 4th year pharmacy student (by the way, Kelli, I don't remember arguing with you).
Now, on the other hand, If sweden would have said, "Perry, tell my why you feel that Plaquenil is safe for the avg person to take". Hey...I love it. I would appreciate his confidence in me in asking the question, and I would do my damnest to find the answer. If I couldn't locate the answer, then I would ask someone (prof) for help, or simply say, "Hey, sorry, I don't know." And this is how, IMO, its supposed to work, and I think that if folks just exercised a little more respect and restraint on these forums, then there would be more harmony and less discord. The End.
Answer: according LEXI-COMP's Drug Information Handbook, 12th ED., 2004 (www.lexi.com) the prevalence of ADR's of Plaquenil are listed as "Frequency not defined". This means that the side effects are so rare (could have happened only once) as to be not quantifiable. All side effects of the drugs are quantifiable above 1 percent. Of couse, I called AU's drug information specialist and she said that FND could mean anywhere from 1/1000 to 1/1000000. So, there you go.
LEXI-COMP is but one of the drug information resorces we use, but is considered by most to be the one of the most comprehensive, in depth drug monograph resources available. In taking drug interactions exams, this resource is one of the most popular resources and rotations students love Lexi bc you get daily updates on your PDA.
Note: Concerning the stats (or lack of) of Plaquenil, it's important to note that most of the ADR info. on drugs comes during phase 2 and 3 of clinical trials, but...also much can be learned from the "postmarket" studies (phase 4) of drugs (the MD's prescribing the drugs report to the manufacturer ADRs, esp, unusual ADR's). My point is that in most areas of the world where the anti-malarials are still used for that reason -- the third world countries (eg the Congo, Indonesia, etc), -- then the reporting of these side effects is not as complete, as say, here in the US, so the prevalence may be higher.
Sweden, to answer your question, I am taking Plaquenil now. My dad took some anti-malarial drug during his two tours of duty in Vietnam, and it just so happens that one of the profs. who taught us the basics of drug ADR's also spoke of the anti-malarials during his tour in Vietnam. Otherwise, I know next to nothing about them. Had to look the info. up.
ps If anyone doesn't agree with the above info. concerning Plaquenil, then don't gripe to me. Call the manufacturer. Email LexiComp. Call your local pharmacy school. Write the FDA. Bitch to your dococtor or pharmacist.
I am not going to argue about this anymore.