There were some good questions about rosacea treatments, time frames and rosacea gene therapy on ESFB board.
All good questions and valid points. I personally see the treatment of rosacea coming in three waves:
1. 0 to 2 years
-- Much better lasers
-- Topical chemicals for better targetting of blood vessels or sebaceous glands
-- Topical angiogenesis inhibitors (prescription) with or without laser
-- Topical constrictors SansRosa (2 to 2.5 yrs)
-- Topical dapsone for rosacea and acne
-- Chemically modified antibiotics for nitric oxide, CAM and VEGF
2. 2.5 to 5 years
-- Topical VEGF inhibitors
-- Tremendous improvement in laser effectiveness
-- Pathogenesis elucidated for subtype 1 and II
-- Rambazole topical and oral substitutes for accutane -- tremendous potential for drug
-- Able to eliminate most symptoms and some triggers
-- Neural blockers (NANC) and sympthatic dilator substance blockade within varicosity (targetted for blushers and rosacea)
-- Better hypathalmic temperature control regulation
-- Blockade and treatment of facial burning sensations (2 to 2.5 years)
3. 6 - 9 years
--Topical gene therapy targetted at inflammation and rosacea genes. Symptom and Trigger Treatment.
-- Left over laser for broken blood vessels
Very rough estimate with time frames and some key drugs and treatments we know are on the way. There are many other experimental drugs that will be added along the way and used off label with great success. Two psoriasis drugs are in Phase IIb that should actually be first line rosacea drugs. These are not only in the pipeline, but coming through the pipe.
There are a lot of unknowns right now with gene therapy and it is a scary term to some. But there is also a heck of a lot known about gene therapy right now. These companies can make any type of gene therpy if you just tell them what gene you want blocked or what gene you want increased. They can make this right now. They can apply all these genes topically and get them into the cells to do their thing. These are two great steps. They have been doing tons of animal studies and benchwork studies in inflammatory skin disorders and are ready to start clinical trials on almost all fronts.