3rd September 2005 09:56 PM
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Topical Gene Therapy Cream for Rosacea
Rosacea Research and Treatment Institute -- Cytogenix Gene Therapy
On September 1, 2005, I had a long follow up conversation with Kurt Berens at Cytogenix and its interest in Rosacea treatment. We spoke about their companies focus on inflammatory skin conditions. He verified that excessive or otherwise inappropriate inflammation is thought to be causative in many human disorders and skin conditions. He stated that his company scientists have found common proteins and expression of certain genes in many of these inflammatory reactions. He also restated Cytogenix's main gene therapy technology, "The Company has applied its technology to silence a powerful inflammation-causing gene and, has applied this sequence to a topical formulation against several inflammatory skin conditions"
They are also very excited about their gene therapy construct CY302 for topical therapy of Rosacea and Psoriasis. As stated on their website, " CytoGenix scientists are developing a topical cream containing the company's proprietary ssDNA expression system engineered to express a sequence that silences a human gene associated with critical early steps in most types of tissue inflammation and several other potential uses for this treatment include dermatitis (contact and atopic), acne and rosacea.
We then further discussed what was needed to get our hands on some of his expensive ssDNA gene therapy to test on rosacea blood vessels. He said he would just need a simple two page description of the investigators, the hypothesis, the protocols and how much ssDNA would be needed. He would make it happen. Very exciting that they are fully on board.
Gene therapy is confusing for most lay people...... and many scientist for that fact. Cytogenix has put together an excellent one page description of how this therapy works and has put together an excellent animation half way down. Please click on the link below, read the page and click on all four animated links under the diagram of the cell:
3rd September 2005 10:07 PM
This is very exciting! Thanks Geoffrey, for pursuing this and for letting us know about it.
4th September 2005 09:57 AM