FYI-Genistein

[prryjones]

Hi all,
There are some studies that testify to the anti angiogenesis properties of genistein (a component of the soybean).
Just FYI.
Perry


Biochem Pharmacol. 2005 Jan 15;69(2):307-18. Epub 2004 Nov 19. Related Articles, Links

The novel targets for anti-angiogenesis of genistein on human cancer cells.

Department of Medical Technology, Fooyin University, Kaohsiung Hsien 831, Taiwan.

Genistein has been reported to be a natural chemopreventive in several types of human cancer. In our prior study, soy isoflavones were shown to induce cell cycle arrest and apoptosis of bladder cancer cells in the range of human urine excretion. This study was designed to identify the novel molecular basis underlying anti-angiogenic activities of soy isoflavones. An immortalized E6 and five human bladder cancer cell lines were studied by immunoassay, flow cytometry, functional activity, reverse transcription-polymerase chain reaction, immunoblotting, and transwell co-culture in vitro. The efficacy of soy isoflavones on angiogenesis inhibition in vivo was examined by nude mice xenograft and chick chorioallantoic membrane bioassay. Factors analyzed included angiogenic factors, matrix-degrading enzymes, and angiogenesis inhibitors. Genistein was the most potent inhibitor of angiogenesis in vitro and in vivo among the isoflavone compounds tested. It may also account for most of the reduced microvessel density of xenografts observed and the suppressed endothelial migration by soy isoflavones. Genistein exhibited a dose-dependent inhibition of expression/excretion of vascular endothelial growth factor165, platelet-derived growth factor, tissue factor, urokinase plasminogen activator, and matrix metalloprotease-2 and 9, respectively. On the other hand, there was an up-regulation of angiogenesis inhibitors-plasminogen activator inhibitor-1, endostatin, angiostatin, and thrombospondin-1. In addition, a differential inhibitory effect between immortalized uroepithelial cells and most cancer cell lines was also observed. Altogether, we discovered that tissue factor, endostatin, and angiostatin are novel molecular targets of genistein. The current investigation provides further evidence in support of soy-based foods as natural dietary inhibitors of tumor angiogenesis.

[snwbdrloco84]

That is interesting Perry. The only I am cautious about soy is conflicting reports concerning guys who eat products with it. Maybe some males with higher than normal testosterone levels would benefit from products with soy since it is estrogenic in nature. Hormones is some we could all get checked. Maybe it would be more for women of the group.

Ray

[prryjones]

Hi Ray,
To my knowledge soy has minimal effect on hormone levels (actually, consuming protein slightly increases testosterone levels, I believe) and is one of the most widely consumed products (soy protein) in the world. Many weight lifting/body building supplements (esp back in the 80's) derive their protein from soy (it's the cheapest form of protein, I think). Also, soy allergy is extremely rare.
Anyway...I think you're referring to the studies linking soy consumption to decreased post menopausal hot flashes in women (this was observed first, I think, in Japan, where soy is more of a dietary stable than in the US).
The data is accumulating, and at least where I went to school, we are taught to counsel soy use as a alternative to hormone replacement therapy regarding hot flashes. I don't think the mechanism of action is known.
If I am incorrect in any of the above, please feel free to correct me.
The reason I posted about soy is simply that it is a very small molecule, fairly fat soluble, which means that a backyard chemist could probably buy pharmaceutical grade genistein and make a topical.
Well...anyway....
Thanks,
Perry

[snwbdrloco84]

Thanks Perry. I wonder what the dosage would even be to make it effective in the inhibition of angiogenesis. It probably could be used to help keep rosacea on a plateau so less damage was being done every time we would flush. Perhaps a few slices of bread with soy protein a day would do the trick...lol

Ray

[prryjones]

Hi Ray,
Maybe not so crazy as we might think. Problem is, most inhibitors of angiogenesis are dose dependent (I THINK), so one would have to consume massive ammts just to get a clinical effect.
This is why a topical sounds very practical.
There are prob. many molecules that are being tested for AI properties that we laymen arent aware of. When the time is right, Dr. Nase will clue us in, I'm sure.
I like to keep an eye out for stuff like this in any event.
Perry