Melanotan

[Kris Jacobs]

Hi Dr. Nase.
Melanotan has been talked about quite a bit here and in past forums by yourself.
When they started clinical trials, many patients were experiencing skin flushing (about 70%)
as the trials went on, they seemed to have addressed the problem and as a result, they had only about 30% of patients experiencing flushing.
now as far as I know, these people were non-rosacea sufferers.
If non rosacea sufferers are experiencing flushing from melanotan, what is it going to do for us rosacea sufferers?
Do you think rosacea sufferers are going to be able to use this product with out making their condition worse?
just curious- I would like to think that I could use this one day because it sounds so promising
thanks a lot
Kris Jacobs :x

[drnase]

Hello Chris,

I was hoping to find out that answer at the University of Arizona where it all started out. One of the original testers was willing to test rosacea sufferers (they had tested Lupus sufferers with normal levels of flushing which is a good sign), but could not get it released from the two companies who bought all the rights.

The shots in the arm were a big problem flushing wise because the blood stream was saturated with the medicine and since the medication has some action on the hypothalamus this is probably the cause of flushing.

As you pointed out, they decreased this substantially by making it into a little pellet and implanting it under the arm for steady release. Still some flushers.

There have been no trials to date on melanotan II and rosacea. So anything I state is just a guess. I sincerely dont think we will have a problem with Melanotan II. The reason? The tan lasts quite long and one can get quite dark quickly. So, smaller pellets with slower time release would decrease the blood concentration even further and possible bring it down to the nanomolar range where the hypothalamus receptors would not "see it" or just transiently have a reaction. So, the first couple treatments might cause a little flushing, but to maintain that degree of tan would be quite easy and only need minute amounts of the medication. Theory I know, but it sounds somewhat rationale.

I'm not sure if i'm allowed to post here, if i'm not please tell me and i'll delete this post. I signed up to be sent the email releases about this and i can remember them stating that the flushing tended to be on insertion as opposed to throughout the time the implant remained.

Personally it concerns me as its actually in the body 24/7 which means if you started reacting badly to it, you would have to go through the process of removing it asap and surely some people may become allergic if their immune systems start trying to eradicate it as a foreign body.

I would much rather take it in tablet form.

[drnase]

Great point Sally,

I dont remember seeing any reactions to it yet; but there will always be reactions to anything.

I like the pill idea.

I also remember Andrew Reid mentioning something about a topical formulation -- but who the heck knows with rosacea skin.

Sally Ann please stay. I am three quarters Italiano and I giggled at your mafioso lingo. Thanks. Now go over and get me a beer.

[Max]

just found a forum where people discuss this topic, some have even tried it.

if anyone's interested:

http://melanotan.org/cgi-bin/yabb/YaBB.pl

oooh intereting site, TERRIBLE colour scheme.