Hi Dr. Nase,
You probably posted the abstract below, but for those that have not seen it, there you go.
It's extremely frustrating to realized that: 1) efficacious meds for us are years away, 2) Most MD's don't really give a hoot about our dissorder, and most of all 3) the technology exists that could greatly increase IPL efficacy, yet isn't being used.
IS the confocal microscope in our near future? I mean reading an abstract about the capabilities of some wonderful new gadget is great, but until some Dr. chooses to give it a try...it's usess IMO.
Do they (MD's) want us to pay for their renting the dang thing or what?
I would pay umpteem more for a laser tx THAT I KNEW WORKED.
Thank you, and this will be my last gripe (maybe) about this subject.
REAL-TIME CONFOCAL MICROSCOPY IMAGING OF ROSACEA IN VIVO
R. Tachihara, C. Choi, R.R. Anderson and S. Gonzalez
Department of Dermatology, Wellman Laboratories of Photomedicine, Massachusetts Genaral Hospital, Harvard Medical School, Boston, MA, USA
Confocal microscopy, Rosacea, Lasers
Rosacea is a common, sunlight-exacerbated inflammatory disorder on the face. The pathophysiology still remains unknown. The clinical hallmarks of rosacea are papules and papulopustules, vivid erythema and telangiectasia. Sometimes histology is required to make differential diagnosis and yet it is often difficult to take a biopsy because of the site.
Confocal reflectance microscopy (CM) can noninvasively image thin en face sections within living skin with high resolution and contrast. The image contrast is mainly due to the detected variation in singly back-scattered light due to variation in the refractive index (n) of tissue microstructures (typically, n=1.33-1.40). A laser scanning confocal microscope was used to image rosacea. Using water immersion objective lenses of numerical aperture 0.7-1.2 and wavelengths of 800-1064 nm, the lateral resolution is 0.5-1.0 microns and the axial (virtual section thickness) resolution is 3-5 microns, comparable to routine histology.
In this research study, we demonstrated that the major features that histologically characterize each clinical stage of rosacea can be visualized in vivo. These features include dilated pilosebaceous units surrounded by dilated and tortuous capillary loops in the superficial dermis, perivascular and perifollicular infiltration of inflammatory cells, and infiltration of neutrophils, forming follicular pustules.
In conclusion, real-time CM may provide a noninvasive tool for studying the pathophysiology of this common disorder, and a clinically useful diagnostic in some cases.