nose flushing

[Souris24]

I have been on clonidine for about a year for general flushing and particularly for bad nose flushes mainly (but not solely) occuring in the evening when relaxing in an armchair or when laying down in bed. This would happen every day without fail. THe clonidine did an excellent job for 6 months but then I started to feel palpitations and pressure again in my nose and I knew it would for sure start to flush again. So, I increased the dose to 75mcg 3x a day and everything was good again for 6 months. About a week ago, the palpitations and pressure feeling in the nose came back and it is now almost constant though my nose does not actually flush. My GP prescribed me moxonidine to try but I would like to know first if anyone knows up to how much one can go with clonidine.Has anyone heard anything from Prof. Chu about that for example ?
My second question would be for Mistica. Mistica, I read the following in one of your post : "Laying down causes a change of blood pressure, but the dozing in the chair trigger is to do with vagal stimulation. In normal people this should be anti inflammatory, but in some rosaceans, it produces the opposite effect. Hence the term, paradoxical inflammation." What is vagal stimulation ? Is it the dozing or the sitting that triggers the flush ? At the moment, just sitting on a chair can trigger the palpitation/pressure feeling. Before taking clonidine, my nose would flush when kneeling down.
Also, the palpitation feeling occurs really quite deep inside the nose. I suppose it is the blood vessels that try to dilate but cannot yet really because the clonidine is still working enough. There is sort of a fight happening in there. But what I find strange is that it takes place deep inside when I would expect it more at a superficial level, just under the skin. I tend to think that my rosacea is due to sun damage as I had quite some sun and sunburnt as a teenage and also because i don't seem to have other issues and no allergies whatsoever. But when I feel all these pre-flush feelings so deep in the nose, I feel there is something else than sun damage.
Sorry for that long post. I must say that all of this overwhelms me and can really take me into dak corners. I am so scared not to be able to control that, so scared of what will happen if I cannot stop the nose flushing when it starts again.
Besides that, the clonidine helps me tremendously with cheeks flushing.

Marie

[Souris24]

No idea regarding my questions ?

[Judworth]

Hello Marie,

I just wanted to say how sorry I am that the issues with your nose have started up again!

I have found that splitting my dose of atenolol down even further has helped with my flushing in general.

Although I was told that a 50mg dose should last all day, by dividing it into 25mg am & pm it really is helping.

Perhaps that will help with clonidine?

(As long as you don't experience rebound flushing of course!).

Hugs Judy x

[Souris24]

Hello Marie,

I just wanted to say how sorry I am that the issues with your nose have started up again!

I have found that splitting my dose of atenolol down even further has helped with my flushing in general.

Although I was told that a 50mg dose should last all day, by dividing it into 25mg am & pm it really is helping.

Perhaps that will help with clonidine?

(As long as you don't experience rebound flushing of course!).

Hugs Judy x

Hi Judy,

Good that you're doing well with Atenolol. I sort of remember, but maybe I am wrong, that Dr Chu told you that they are people who need a stronger dose of clonidine to have their flushing under control (I mean stronger than 0.75mg 3x a day). Do you remember that or am I wrong ?
As for splitting clonidine, I already take it 3 x a day so I don't think I can split it more.
Thanks for you answer.
Take care.
Marie

[Mistica]

Hello Marie,

Sorry for the tardy reply. I have on going internet issues and most days it doesn't work at all. My tech is due soon, so hopefully he can sort this out.

Vagal Stimulation. Here is the blog where I got it from. I used to speak daily with P.Ayers and he spoke at some length about it.

http://coolinginflammation.blogspot....lammation.html

I do believe it is far more complex than he outlines here.
Vasodiation is good for general inflammation as it allows fluids to drain away, but rosacea already involves vasodilation, so more isn't a good thing at all.
Much, much worse if flushing is involved too. Rosacea/flushing are in a realm of their own.

I think you may be building a tolerance to your drugs and perhaps in the end, they will make flushing worse?
I found that with the topical version. It was hell getting off the brimonidine.

[Souris24]

Thanks for your answer Mistica. I have the feeling that it is my nose only that is building a tolerance to the clonidine though, since a couple of days it is much much better. I don't feel it so much any more. As to my cheeks, they haven't been flushing for days. It's been pretty hot today and I wasn't red at all. If my nose keeps improving I shall be fine.