I am not knocking it, but care needs to be taken when recommending products so as to not get people's hopes up too much with talk of cures after just a few days. As I said those with rosacea need to be especially careful when trying new products.
I am not knocking it, but care needs to be taken when recommending products so as to not get people's hopes up too much with talk of cures after just a few days. As I said those with rosacea need to be especially careful when trying new products.
I see your point, but how are we going to measure whether something works unless people try it? That was said in my original post.
God knows there is plenty of suffering. More negativism is the last thing helpless people need. Teach a man to fish, right?
Let's work together. This is not a race to prove people wrong without even an effort to try the hypothesis. It's a race to keep experimenting until we nail this thing.
If is preferred that I keep my progress a secret for fear it might over-encourage someone, what good would that be?
In truth, I fear my condition could regress. I want to try to stay ahead of the game. What has occurred for me is fast results, but I am leery. I've seen all the multiple, failed efforts. Perhaps what I have done could be tweaked by somebody to put the final nail in the coffin on this condition. That's what I'm hoping will happen.
If enough people try and have good results, certainly some of them will try little variations which might work even better. Then, that could be useful for me, too.
I posted the below excerpt in another thread. This is on-point. It discusses trials with SD patients. The short of it is that by week 3, 6 of 10 patients completely cleared, and the other 4 showed moderate improvement. That's not bad. Not even 1 in 10 said, "I got nothing out of it."
This is the info. on the study I posted:
Here is a recent article released on butenafine which says it is effective against Malasezzia yeasts. http://www.skintherapyletter.com/download/stl_7_7.pdf
Here is the study abstract where butenafine was tested and found effective on seb derm:
RESULTS: Butenafine exhibited almost the same activity as clotrimazole against M. furfur , whereas, naftifine was about eight times weaker in activity compared to butenafine. Tolnaftate did not demonstrate activity against M. furfur up to 100 µ g/ml. By one week of butenafine HCl cream 1% treatment there was already nearly complete suppression of M. furfur growth in vivo compared to baseline. M. furfur was essentially absent in every subject by two weeks. Butenafine HCl cream 1% treatment was effective in eliminating M. furfur from microcomedones and was well tolerated. With regards to the efficacy of butenafine HCl cream 1% in facial seborrheic dermatitis by week three, six of ten subjects had cleared and the remaining four exhibited moderate improvement. CONCLUSION: Butenafine exhibits in vitro and in vivo activity against Malassezia species, being markedly more effective than naftifine and with about the same activity as clotrimazole in vitro. In a pilot study butenafine demonstrated effectiveness in the topical treatment of seborrheic dermatitis. The results need to be confirmed in a larger trial. (J Dermatol Treat (2000) 11:79-83) http://www.informaworld.com/smpp/814...ent=a713931920
I read your post Jeff
Alot of what you said makes sense and I like your approach.
I am also doing alot of research now & in the next few months.
I'm hoping for a cure, but at the least would like to make the symptoms as little as
possible.
Maybe we can colaberate are findings. I'm gonna be started my own different treatment
in a week or so when I get everything I need. I'm optimistic that I will have positive results.
Thanks. I sure hope we can all work together and find a "best" solution, if not a cure.
This PM, I played basketball a little, and got a little itchiness back near the cheek folds, close to the nostrils. Nothing real bad, but it's a nice reminder that there's still more to be done.
Best of luck to all of us. I still remain convinced it's a fungal issue more than anything else. Fungi can be very stubborn and are reported to develop resistance to anti-fungal agents. I posted one editor's comment in a medical journal article that advised that while butenafine can be good, fungal tachyphylaxis (ability to grow resistance) might call for rotation of anti-fungal agents in order to stay a steady step ahead of the fungi.
The problem with the rotation idea is, "Where to rotate next?" If you try to rotate to the wrong thing, it could be all the way back to square-one. There are just too many possible combinations. So, if my regimen does not exhibit long-lasting success, I really am at a loss to determine to what I will turn next.
Here is yet another abstract on butenafine:
RESULTS/CONCLUSIONS: The drug has excellent penetration into the epidermis and a prolonged retention time following topical application, conferring residual therapeutic activity after treatment cessation. Butenafine possess anti-inflammatory activity too. Topical butenafine 1% cream has been reported to be efficacious for tinea pedis, tinea corporis and tinea cruris in many randomized clinical trials when used for shorter duration. Its efficacy against pityriasis versicolor, seborrheic dermatitis and as anticandidal agent is not yet fully established. http://www.ncbi.nlm.nih.gov/pubmed/18624686
The underlined segment explains why I had good relief last Thursday night which enabled me to go to sleep within about 20 minutes, where before, I was itching so bad, I didn't think I would get to sleep. Perhaps at the least, it can replace steroids, which can be bad news.
Hi Jeff,
I've read your posts and I'm happy your seeing some reduction in your SD symptoms. This is great news.
Know that while you've seen remarkable improvement in four days, SD often goes in periods of remission/flares during different times.... For example, as seasons change, stress, diet, GI issues, etc.. I agree with you anti-fungal supplements can help, but unfortunately there isn't a cure (atleast none known). Many things can help SD, true. While we'd like to hear your progress, the protocol you suggest may not work for others. I'm sure you can understand we don't want to give folks false hopes or think they can cure their SD in four days buying the products you mention. You may find too, you may need to "tweek" your program here and there as needed. It's a work in process if you will.
Thanks again for sharing.
Yvette
It seems I am hitting that resistance period I discussed in prior posts. A bit itchier today. Trying to be careful not to scratch. Still in good shape, but not as good as yesterday morning and the few days before it.
I wish I knew where to from here.
Couple of points:
It seems to me a bit unlikely that it is seb derm, at least any classic seb derm (malassezia) because of the abrupt onset. From my experience, that isn't the usual pattern.
Second point re, seb derm: topical anitfungals against seb derm are usually found (apparently) to have an effect over a period of weeks rather than the small number of days in which you're experiencing effects. Just suggests something else might be going on. (I say "apparently" since none has worked with me, period).
Following on, one thing that can have a quick effect is a sudden change in the topical cleansing regime. So, if you suddenly change to using something oil-based, or with lots of emulsifiers or whatever. This should be in your thinking (I haven't read your accounts closely enough to know whether it tallies).
Don't disregard the gut. The abrupt onset might seem to contradict this, but in my experience, changes to the gut flora can have effects quite quickly. And changes in regime (less sugar, feeding bacteria in your small intestine, or antifungals, or whatever) can likewise have quite dramatic effects.
My 2 pence.
FYI, I switched to ketoconazole last night. Seems to have abated what was otherwise headed toward a relapse. I'll keep you posted.
The reason for the switch is not to abandon butenafine, but to rotate between medicines due to the tendency to become resistant to a given drug - the "tachyphylaxis" which I have mentioned in other posts.
So far, still pretty good..... quite tolerable.
you've been very generous with your posts Jeff. thank you so much for sharing--putting the info out there for another, taking the time. regardless if it works or no (hope it does).
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