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Thread: Klaron

  1. #1
    Senior Member mutantfrog's Avatar
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    Question Klaron

    Hello,

    I am looking for any reviews/experiences with the topical Klaron (sodium sulfacetamide lotion, 10%). I did some searches, and found some mention of this drug. However, many of the posts (at least the ones I saw) were either a little dated or mentioned Klaron more in passing. In some other searches I've done online, it seems Klaron has been prescribed for acne, not necessarily rosacea. I am hoping for any additional or up to date reviews of Klaron.

    It's been prescribed to me for rosacea and perioral dermatitis. I tend to get mainly red/hot flushing and swelling on my cheeks and around my eyesockets, with some bumps on my cheeks. Then just red, burned feeling skin right around my nose and under my bottom lip. I guess that's the "perioral dermatitis" aspect? I tend to have slightly oily skin. I did not tolerate metrogel well (just caused insane redness) and finacea worked ok on my cheeks (helped with sensitivity, but caused breakouts on other parts of my face). Weirdly, topical erythromycin worked OK--I was expecting disaster with this because of the alcohol in the solution, but it did not cause a flare. Did not significantly reduce redness (though was helpful with the bumps), which is why the derm is wanting to try Klaron. Yet, BP made my skin go nuts (even though the alcohol in erythromycin didn't--bizarre).

    Anyways, I'm just looking for reviews or input about this drug.

    Thanks!

  2. #2
    Senior Member Mistica's Avatar
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    Myself and a few others use the combination Sulfacetamide/sulphur as a wash, or short contact treatment and have found benefit.
    Personally I have found it a 'must' in my battle, particularly in reducing inflammation.

    MissD is the only one I know of who uses Sulfacetamide 10% on it's own and I believe she leaves it on. Hopefully she will step in and provide better feedback than I can give.

    Incidentally, Quercetin/bromelain can also help reduce swelling. I take this.
    On a downside, it appears that quercetin can increase Cpn, so if this does play role in rosacea, it is better to keep the dose to a minimum.
    Previous Numerous IPL, ZZ cream.
    Supplements: Vit K2, High Dose Vit C, BHCL, Digestive Enzymes, Ionic trace mineral drops, low dose iodine to correct deficiency.
    Skin Care: Cetaphil Gentle Cleanser, or ZZ soap.

    Treating for gut infections under specialist care. (This is helping).
    GAPS diet foods/no probiotics.

  3. #3
    Senior Member mutantfrog's Avatar
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    A wash? Really? I sort of assumed that a medicated wash would not be on my skin long enough to make a difference one way or another (I was told that salicylic acid in a wash was pointless for this reason, back when I was battling just acne and not rosacea). I will ask my derm about it. I way prefer not to use topicals if possible...I have yet to run into one that did not cause trouble. The topical eryth. is probably an exception, but I'm not sure that it helped more than 15% or so for redness.

    Has anyone with dermatitis (any kind) been prescribed this, if so, how have you fared with it? As opposed to just rosacea...

    I've been using it since July 2nd, 2x/day...it doesn't burn, but my skin does feels a little tight/slightly dry later in the day (and i have oily to normal skin). The texture of my skin is better already--SO smooth, no bumps--but I am noticing more intense redness and a bit of burning sensation around my nose/bottom of my chin ("perioral dermatitis"). Frustrating that so many different medications work wonderfully for one part of my face but not the other. It is like dr jekyll and mr hyde...

    Any other opinions/comments about Klaron specifically? Related topicals?

    Thanks

    **Mistica-- what is "bromelain"? I have never heard of this. I assume some kind of vitamin/herbal supplement?

  4. #4
    Senior Member chenoarae's Avatar
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    I too used the wash but found it did nothing for me - except dry me out toward the end of 2 months of regular use.

    My papules are of the intensely stubborn variety though - and you may be correct in that the wash isn't on long enough to make a difference (though I couldn't have tolerated longer what with the dryness).

  5. #5
    Senior Member queta's Avatar
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    Default Quercetin and cpn

    Quote Originally Posted by Mistica View Post
    Myself and a few others use the combination Sulfacetamide/sulphur as a wash, or short contact treatment and have found benefit.
    Personally I have found it a 'must' in my battle, particularly in reducing inflammation.

    MissD is the only one I know of who uses Sulfacetamide 10% on it's own and I believe she leaves it on. Hopefully she will step in and provide better feedback than I can give.

    Incidentally, Quercetin/bromelain can also help reduce swelling. I take this.
    On a downside, it appears that quercetin can increase Cpn, so if this does play role in rosacea, it is better to keep the dose to a minimum.
    Hi Mistica
    What does Cpn mean? Could you please tell more about the role of Cpn in rosacea and its relationship with quercetin? I'm still taking the quer/brom combo faithfully and want to find out any possible negative effects.
    Thanks so much
    Queta
    "Do not go where the path may lead, go instead where there is no path and leave a trail."
    Ralph Waldo Emerson

  6. #6
    Senior Member Mistica's Avatar
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    Hi Queta,
    Cpn = Chlamydia pneumoniae.

    According to one expert in the field Quercetin is a useful agent in killing Cpn.

    See:

    http://www.cpnhelp.org/taxonomy/term/55

    Dr. A- Not only the tissue penetration, but also both the organism and your cells have active efflux pumping mechanisms to pump out the antibiotic. You have to work against these natural mechanisms to keep adequate concentrations in the cells. Rifamcin tends to inhibit these efflux pumps. I also use another drug, Quercetin, a bioflavonoid that also acts as a cell efflux inhibiter. It works on a different efflux pump than Rifamcin. Itís, also active against Chlamydia on itís own.
    However the following study seems to dispute this.

    http://cat.inist.fr/?aModele=afficheN&cpsidt=17129696

    quercetin increased both the inflammatory responses and the chlamydial load in the lungs. The infection and inflammation-enhancing effects of quercetin treatment may be attributable to the dose and the route of administration and should be reassessed in further studies with lower doses or with different metabolites of the compound.
    Hopefully if Dan sees this post, he will add his thoughts. I do know he is against taking Quercetin.
    Personally, I still take it ( for now) as without it my face becomes even more inflamed and swells.

    I currently take 1 to 2 tablets per day. Sometimes 3.

    Of course, the above science is only of value if you support the theory of Cpn being at least a secondary cause of rosacea.
    Your type of rosacea (phymatous) is very different from the standard, so I have no idea where it fits in.

    I assume you are continuing to see very pleasing results?
    Last edited by Mistica; 16th July 2009 at 11:15 PM.
    Previous Numerous IPL, ZZ cream.
    Supplements: Vit K2, High Dose Vit C, BHCL, Digestive Enzymes, Ionic trace mineral drops, low dose iodine to correct deficiency.
    Skin Care: Cetaphil Gentle Cleanser, or ZZ soap.

    Treating for gut infections under specialist care. (This is helping).
    GAPS diet foods/no probiotics.

  7. #7
    Senior Member queta's Avatar
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    Default Quercetin

    Quote Originally Posted by Mistica View Post
    Hi Queta,
    Cpn = Chlamydia pneumoniae.

    According to one expert in the field Quercetin is a useful agent in killing Cpn.

    See:

    http://www.cpnhelp.org/taxonomy/term/55



    However the following study seems to dispute this.

    http://cat.inist.fr/?aModele=afficheN&cpsidt=17129696



    Hopefully if Dan sees this post, he will add his thoughts. I do know he is against taking Quercetin.
    Personally, I still take it ( for now) as without it my face becomes even more inflamed and swells.

    I currently take 1 to 2 tablets per day. Sometimes 3.

    Of course, the above science is only of value if you support the theory of Cpn being at least a secondary cause of rosacea.
    Your type of rosacea (phymatous) is very different from the standard, so I have no idea where it fits in.

    I assume you are continuing to see very pleasing results?
    Hi Mistica
    Thanks so much! Yes, I am getting better and better. I wonder if my problem is related to Cpn. I seem to have some of the other symptoms and my skin is getting better and better as I use the quer/brom. I'm not saying that my problem is related to Cpn, but it's an interesting thing to consider. Maybe I'll post about it on a new thread at some point...I don't want to take this thread too far off its original topic. I agree with you that phymatous rosacea seems to be very different from the more vascular types. One well-respected derm thinks it is a separate disease. Anyway, I couldn't be more pleased with the effectiveness of quer/brom. It has improved my quality of life. I have had tingling throughout my body for the past 18 years (I've been checked for MS and other things but they never found anything) and it seems like that symptom is improving as well. Life is good.
    Regards and thanks again,
    Queta
    "Do not go where the path may lead, go instead where there is no path and leave a trail."
    Ralph Waldo Emerson

  8. #8
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    Default

    Quote Originally Posted by mutantfrog View Post
    Hello,

    I am looking for any reviews/experiences with the topical Klaron (sodium sulfacetamide lotion, 10%). I did some searches, and found some mention of this drug. However, many of the posts (at least the ones I saw) were either a little dated or mentioned Klaron more in passing. In some other searches I've done online, it seems Klaron has been prescribed for acne, not necessarily rosacea. I am hoping for any additional or up to date reviews of Klaron.

    It's been prescribed to me for rosacea and perioral dermatitis. I tend to get mainly red/hot flushing and swelling on my cheeks and around my eyesockets, with some bumps on my cheeks. Then just red, burned feeling skin right around my nose and under my bottom lip. I guess that's the "perioral dermatitis" aspect? I tend to have slightly oily skin. I did not tolerate metrogel well (just caused insane redness) and finacea worked ok on my cheeks (helped with sensitivity, but caused breakouts on other parts of my face). Weirdly, topical erythromycin worked OK--I was expecting disaster with this because of the alcohol in the solution, but it did not cause a flare. Did not significantly reduce redness (though was helpful with the bumps), which is why the derm is wanting to try Klaron. Yet, BP made my skin go nuts (even though the alcohol in erythromycin didn't--bizarre).

    Anyways, I'm just looking for reviews or input about this drug.

    Thanks!
    I was given "sulfacetamide sodium topical suspension UPS, 10%"... a.k.a., generic Klaronģ... 10 days ago by my newest (and most completely useless) dermatologist and so far it has been absolutely worthless. At first it just did nothing (good or bad)... but after six days it started to have a negative effect. Yesterday, I had to quit it altogether and even apply Caladryl lotion overnight to help get my skin back under some sort of temporary, short-term control.

    My whole miserable history with rosacea is summarized here:
    http://rosaceagroup.org/The_Rosacea_...ad.php?t=18730

    Topicals have been universally bad for me long-term... so please take that into consideration. In my particular case, they always end up doing more harm than good. The new derm was told this fact, but refused to listen.

    C.L.M.N.

  9. #9
    Senior Member mutantfrog's Avatar
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    Just wanted to post an update, as I've been using the Klaron for almost 2 months now.

    Initially, I was not so pleased with the Klaron. My dermatologist suggested that I might be using too much--when applying she had me put only about 1/2 of a dime sized amount on my whole face. I wasn't using much more than that to begin with, but I followed her instructions. I was dubious, but I figured--what the heck. I know with other topicals there's that fine line between "enough" and "too much", which gives gross looking side effects.

    After sticking it out for 2mo, I would say yes--the Klaron DOES help. My skin texture is better, and SMOOTH--I have no bumps anywhere. I used to have sort of a smattering of tiny bumps--not always red, and not whiteheads (there was nothing in them), just...bumpy. The ones on my cheeks and occasionally on my nose used to be red.

    *however*-
    It reduced redness on my face everywhere except for the perioral derm stuff (corners of my mouth, under my lip) and the more intense redness areas on my cheek (under my eye, about quarter-50cent sized pieces on both sides).
    My skin also feels better in terms of burning. Like, it feels very normal, and less reactive.

    I sort of took matters into my own hands regarding the remaining redness.
    I figured since finacea worked on my cheeks, I'd add that there and since metrogel worked for the perioral derm, I would use metrogel on that area--both on top of the Klaron. These topicals (finacea, metrogel) were both DISASTERS when I tried to use them over my whole face, individually.
    I started that about a month ago.

    So Klaron 2x a day (all over, morning and night)
    Finacea on a small amount of my face 1x day (cheeks, at night)
    Metrogel on a small amount of my face 1x day (corners of nose, under lip, at night)

    And it's actually working REALLY well. Yes, my skin is still a little pinker than the average person's might be. Yes, I still flush sometimes when it's hot out or I get really embarrassed/nervous. But they recover pretty quickly, and it doesn't hurt (it's just red). This is the best my skin has looked since I was 12yrs old. I've had a few mornings when I wake up and there is no red at all in my skin. Which was sort of weird...it's like I almost didn't recognize myself with out the red patches everywhere, they've been there for so long. It's surprising just how different i looked w/o it.

    I am still taking oral erythromycin. Initially I was taking 333mg 3x day when i started the topicals (I've been on an oral AB in some form for years). I've been able to cut that down to 1x day--started that about 3 weeks ago. No increase in skin irritation. So I am hopeful that I can maybe eliminate the oral AB. I used to have swelling around my eyes (like around the edge of the eyesocket area) without oral AB's--so the fact that I have reduced it and it hasn't come back makes me really hopeful.

    Normally I do not tolerate topicals well, but i gotta say, in this case...I'm glad I was wrong.

    I've also cut out moisturizers completely (the Klaron feels like a moisturizer when i put it on--cuts the burning, oddly enough). I use Aquanil to cleanse 2x day.

    I hope that this helps someone!

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