Hey everybody, I thought this article from may 2004 was very interesting. To access the full article you have to purchase it from www.blackwell-synergy.com. The thing i would like to know is what substance was used to reduce the gut transit time. I guess we'll have to read the entire article to find this out. The most interesting thing in my mind and in my opinion is that rosacea is really something that has to be treated from WITHIN. I don't think a topical will ever cure us. There's something wrong inside of us. I strongly believe this. And it may very well have to do with our digestive system and if not, I think it def plays a major role. What we eat, how we eat, and how our digestive system works. I copied and pasted the abstract below. Tell me what you think. -Chris
Rosacea is a chronic disorder characterized by hypersensitivity of the facial vasculature, presenting with intense flushing eventually leading to chronic erythema and telangiectasia. Although the precise aetiology of rosacea is not known, numerous associations with inflammatory gastrointestinal tract disorders have been reported. Furthermore, substance P-immunoreactive neurones occur in considerably greater numbers in tissue surrounding affected blood vessels suggesting involvement of neurogenic inflammation and moreover plasma kallikrein–kinin activation is consistently found in patients. In this report, a patient without digestive tract disease is described, who experienced complete remission of rosacea symptoms following ingestion of a material intended to sweep through the digestive tract and reduce transit time below 30 h. It is possible that intestinal bacteria are capable of plasma kallikrein–kinin activation and that flushing symptoms and the development of other characteristic features of rosacea result from frequent episodes of neurogenic inflammation caused by bradykinin-induced hypersensitization of facial afferent neurones. The possible relevance of this hypothesis to other conditions featuring afferent hypersensitivity, such as fibromyalgia, is considered.
*Experimental dermatology • Concise report
Remission of rosacea induced by reduction of gut transit time
* S. N. Kendall
Mathematics Institute, University of Warwick, Coventry, UK
S. N. Kendall, Mathematics Institute, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.