In support of the notion that the EGF-R is central to the development of rosacea is the observation that EGF-R blocking pharmaceuticals elicit erythematous papules and follicular pustules (7-9) that likely occur because of an overexpression of the EGF-R in keratinocytes.
In regard to diet, the following substances also bind the gut EGF-R and gain access to circulation:
1. Wheat germ agglutinin (WGA) a dietary lectin which is found in both whole and refined wheat products (10).
2. Peanut agglutinin (PNA) a dietary lectin which is found in peanuts (11).
3. Tomato lectin (TL), a dietary lectin which is found in tomatoes (12)
4. Phytohemmagglutinin (PHA) a dietary lectin which is found in kidney beans and all other Phaseolus vugaris bean varieties (13, 14)
5. Soybean agglutinin (SBA) a dietary lectin which is found in all soybeans and soy products, whose specifity is to one of the sugars in the EGF-R (15)
6. Betacellulin (BTC) a hormone found in milk and cheese which is a natural ligand for the EGF (16, 17).
7. Egg white lysozyme, a lectin found in the whites of eggs