Angiostat

[grace]

FYI, I stumbled upon this product several weeks ago during my own research/search for natural angiostats (anti-angiogenesis). Thought it would be of interest, especially to those seeking natural alternatives.

Allergy Research Group (aka Nutricology), for those not familiar with this company, they are one of the leading innovators of cutting-edge nutraceuticals, has recently come out with a new product called "Dermaweed" to treat skin conditions specifically caused by angiogenesis. Although their patent mainly states for the treatment of psoriasis (see link below), it seems applicable for rosacea.

The angiogenetic ingredient in Dermaweed is sea bindweed, (Calystegia spp) the other ingredient is Sophora flavescens which is a chinese herb that eliminates heat in the body.
fyi, ARG also has a product called Vascustatin (formerly known as AngioBlock) which has been out for quite some time and has the angiogenetic ingredient of field bindweed (Convolvulus arvensis) which is mainly a treatment for cancer. Although similar in action, they are two different plants. Per their studies, field bindweed is 100 times more potent than shark cartilage for preventing angiogenesis. And sea bindweed is 4 times more potent than field bindweed and has an affinity to the skin. I do not know how this potency compares to the sea cucumber in AngioStop, which is mentioned on Nase's website.

Here is a link to the patent, dated September 2005:
http://www.wipo.int/pctdb/en/wo.jsp?...9&DISPLAY=DESC

Here's is a link to how bindweed's angiostat properties got discovered:
http://findarticles.com/p/articles/m...ay/ai_85131525

Dermaweed is currently available on the ARG website:
http://www.allergyresearchgroup.com

Below are excerpts from the patent text:

The present invention relates to compositions for inhibiting angiogenesis, for treatment of skin conditions including eczema and psoriasis.

A "skin condition" or "skin condition characterized by inflammation" as used herein refers to a skin condition characterized by redness, localized heat, swelling, pain, and itching.

Anti-Angiogenic Angiogenesis refers to the formation and the growth of new blood vessels. Angiogenesis occurs in the healthy body for healing wounds and for restoring blood flow to tissues after injury. The healthy body controls angiogenesis through angiogenesis-stimulating growth factors and angiogenesis inhibitors.

Without being limited as to theory, it is thought that most anti-angiogenic agents work by preventing the growth of the endothelial cells that form the inner lining of the blood vessels, which prevents formation of new blood vessels (Griscelle et al., 1998). Other anti-angiogenic agents work by signaling cascade or by blocking the ability of endothelial cells to break down the extracellular matrix (National Cancer Institute). Anti-angiogenic agents may further target vascular endothelial growth factor (VEGF), receptors for VEGF, integrins, matrix metalloproteinases, and other blood vessel targets

The composition is one that includes an extract of sea bindweed, Convolvulus soldanella (also called Calystegia soldanella). As illustrated below, this compound has been found to be effective as an anti-angiogenic agent. As further illustrated below, this compound has been found to effectively reverse or reduce the symptoms of inflammatory skin conditions such as eczema and psoriasis.

[phlika29]

Grace

Thanks for the information, this is very interesting. I have looked at the Dermaweed and am interested in purchasing some.

From the link provided this is only for health care professionals to buy and they redirect you to another website where it doesn't seem to be available. Have you tried to buy any?

Sarah

[grace]

Sarah, I was able to place an order over the phone:
800-545-9960
510-263-2000 (outside US)

[orangehorizon]

I can't wait to hear for your results if any. Please consider application only to half of face to spot any effect or zero effect.

[SoSickOfThis]

Re: Please consider application only to half of face to spot any effect or zero effect.

I believe this only comes in pill form, or is there also a topical?
Also, what is the price for a bottle of this? It sounds interesting, but I wouldnt try it if its too expensive. Especially since they say to take 9 to 15 pills a day. Which means the bottle would only last 8 to 13 days.

[DukeCity]

Grace -- What price and for what quanity???

[grace]

Sorry, I thought the website had pricing. I purchased it directly from ARG and I think the price was ~$35-$40 a bottle (120 capsules). The recommended dosage is 3-5 capsules 3x a day. So it is pricey - if you search on the net, you may be able to find it a bit cheaper, I think the lowest price I was able to find was $30. I'm going to try it for at least 3 months and see how it works for me. I will post any significant update.

[SoSickOfThis]

Thats a little too expensive for my tastes. If you took the full 15 pills a day this would cost $90 for 24 days. Even if you only took the lower dose of 9 pills a day it would still cost about $65 -$70 a month. At that price it better completely cure me. This is probably just a waste of money, just like almost everything else.

[DukeCity]

Well worth the price, if taking it the 2 weeks post any IPL/Laser treatment.

[mwilson21]

Does anyone has a direct link to this stuff?