CollaGenex Pharmaceuticals is Awarded $962,000 NIH Grant

[adyus]

Sounds very good, doesn't it? Rosacea is mentioned in the article.


CollaGenex Pharmaceuticals is Awarded $962,000 NIH Grant to Support Research of Potent Anti-Inflammatory Effects of Incyclinide (Col-3)

http://www.genengnews.com/news/bnitem.aspx?name=1101052XSL_NEWSML_TO_NEWSML_WEB.x ml

And...the phase 2 results for COL-3 for rosacea:

http://www.corporate-ir.net/ireye/ir_site.zhtml?ticker=CGPI&script=410&layout=-6&item_id=738428

Best wishes,

Adrian

[Bob Bear]

Cheers Adyus for the heads up. Actually I posted that second link a while back on ESFB - sounds very promising. Geoffrey reckons that they are really going to town on this one. Well, the million dollar grant would certainly suggest that!

Its been a long wait, but finally these companies are realising that we exsist (and have crispy fivers ready to be spent!).

[drnase]

Cheers Adyus for the heads up. Actually I posted that second link a while back on ESFB - sounds very promising. Geoffrey reckons that they are really going to town on this one. Well, the million dollar grant would certainly suggest that!

Its been a long wait, but finally these companies are realising that we exsist (and have crispy fivers ready to be spent!).



For the record, "I told you so". I published about this when it was only a twinkle in Dr. Klaus Theobald's eyes based on its tremendous results in certain forms of skin cancer. He was thinking rosacea all the way. To put that much money into one single drug is to literally put up the house for this one drug on rosacea symptoms -- nitiric oxide, ICAM and neutrophils.

[adyus]

Hello Dr. Nase.
You are right, you did mention this before.
Oracea and Col-3 seem to be similar( these are based on the IMPACS technology, I assume both are modified tetracyclines...). Do you think that these drugs will address other rosacea symptoms such as flushing? I read that their tests focused mainly on inflammatory lessions and the reduction of this number. Am I correct that this number represents the number of papules and pustules?
So....basically, do you think that Collagenex's products will have a direct effect on flushing/erythema/swelling or just an indirect effect by diminishing inflammation(similar to normal antibiotics)? I see you mentioned nitric oxide and neutrophil migration.


Best wishes,


Adrian

[drnase]

Hello Dr. Nase.
You are right, you did mention this before.
Oracea and Col-3 seem to be similar( these are based on the IMPACS technology, I assume both are modified tetracyclines...). Do you think that these drugs will address other rosacea symptoms such as flushing? I read that their tests focused mainly on inflammatory lessions and the reduction of this number. Am I correct that this number represents the number of papules and pustules?
So....basically, do you think that Collagenex's products will have a direct effect on flushing/erythema/swelling or just an indirect effect by diminishing inflammation(similar to normal antibiotics)? I see you mentioned nitric oxide and neutrophil migration.


Best wishes,


Adrian


Hi Adrian,

That is what I cannot understand. I really like Collagenex, especially after talking to their guru, Dr. Theobold who has an absolute passion for rosacea.

What I dont understand yet:

1. Periostat was a good addition for rosacea and periodontal disease -- come people cant or dont want to take antibiotics long term.

2. Oracea has just received a New Drug Application (NDA) and is scheduled to reach the markets in 2006 (3rd or 4th quarter). This is just one time release pill and will put their first medication out of business.

3. Now this third antibiotic has several chemical modifications and works on more symptoms and triggers and once it come out will put oracea out of business. This pill may be 2 to 3 years away though.

I just dont know why they are investing so much money into each drug and then out doing themselves?

[Bob Bear]

Cheers Adyus for the heads up. Actually I posted that second link a while back on ESFB - sounds very promising. Geoffrey reckons that they are really going to town on this one. Well, the million dollar grant would certainly suggest that!

Its been a long wait, but finally these companies are realising that we exsist (and have crispy fivers ready to be spent!).



For the record, "I told you so". I published about this when it was only a twinkle in Dr. Klaus Theobald's eyes based on its tremendous results in certain forms of skin cancer. He was thinking rosacea all the way. To put that much money into one single drug is to literally put up the house for this one drug on rosacea symptoms -- nitiric oxide, ICAM and neutrophils.

I believe you first mentioned it on your sub forum here - you spoke of a Nitric Oxide inhibitor that was being used for cancer but would likely be very effective in rosacea. Not sure if this is the same thing, but either way its fantastic news!

Again, nothing spells business more than a 1 million dollar investment. :wink:

[drnase]

Hello Dr. Nase.
You are right, you did mention this before.
Oracea and Col-3 seem to be similar( these are based on the IMPACS technology, I assume both are modified tetracyclines...). Do you think that these drugs will address other rosacea symptoms such as flushing? I read that their tests focused mainly on inflammatory lessions and the reduction of this number. Am I correct that this number represents the number of papules and pustules?
So....basically, do you think that Collagenex's products will have a direct effect on flushing/erythema/swelling or just an indirect effect by diminishing inflammation(similar to normal antibiotics)? I see you mentioned nitric oxide and neutrophil migration.


Best wishes,


Adrian


Hi Adrian,

Yes, this third antibiotic is different than doxy and they can go up to 500 or even 1,000 mgs and not have any antibacterial actions. With its actions on NOS and VEGF, it will address some forms of flushing or at least help knock it down to bearable.