prryjones
20th September 2005, 06:28 PM
Hi all,
Not new, but interesting study below.
I can't respond to threads at the present time (?), so Geoff...yes, I am referring to minocyclines proven role in AI. Also, I am not familiar with the shark cartilidge topical you're referring to....
Irish...both men and women synthesize both testosterone and estrogen (the molecules are very, very similiar...both come from cholesterol), not too dangerous, but not very helpful in my case either. The hypertension did surprise me, but it sometimes occurs as a result of HRT in post menopausal women, also.
Prob a dumb move on my part, but hey...gotta try.
Fanta...keep your hands to yourself. It ain't that kind of party.
Perry "the 138th most intelligent person on this forum" Jones
Nutr Cancer. 2001;41(1-2):119-25. Related Articles, Links
Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production.
Tang FY, Meydani M.
Vascular Biology Laboratory, JM USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Epidemiological and animal studies have indicated that consumption of green tea and high vitamin E intake are associated with a reduced risk of developing certain forms of cancer. However, the inhibitory mechanism of green tea catechins and vitamin E in angiogenesis, an important process in tumor growth, has not been well established. In the present study, alpha-tocopherol and several major catechins of green tea (catechin, epicatechin, epicatechin gallate, epigallocatechin, and epigallocatechin gallate) were tested for their ability to inhibit tube formation in vitro using a model in which human microvascular endothelial cells were exposed to a constant rate of a physiologically low level of H2O2. In this model, the production of interleukin (IL)-8 by human microvascular endothelial cells at a low level of H2O2 was required for angiogenesis, as assessed by tube formation in three-dimensional gel in culture. Vitamin E (d-alpha-tocopherol, 40 microM) in the culture media significantly reduced IL-8 production and angiogenesis. Among the green tea catechins, epigallocatechin (0.5-1 microM) was the most effective in reducing IL-8 production and inhibiting angiogenesis. These results suggest that consumption of green tea catechins or supplemental intake of vitamin E may have preventive effects on tumor development, mediated, at least in part, through inhibition of angiogenesis via suppression of IL-8 production.
PMID: 12094614 [PubMed - indexed for MEDLINE]
Not new, but interesting study below.
I can't respond to threads at the present time (?), so Geoff...yes, I am referring to minocyclines proven role in AI. Also, I am not familiar with the shark cartilidge topical you're referring to....
Irish...both men and women synthesize both testosterone and estrogen (the molecules are very, very similiar...both come from cholesterol), not too dangerous, but not very helpful in my case either. The hypertension did surprise me, but it sometimes occurs as a result of HRT in post menopausal women, also.
Prob a dumb move on my part, but hey...gotta try.
Fanta...keep your hands to yourself. It ain't that kind of party.
Perry "the 138th most intelligent person on this forum" Jones
Nutr Cancer. 2001;41(1-2):119-25. Related Articles, Links
Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production.
Tang FY, Meydani M.
Vascular Biology Laboratory, JM USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Epidemiological and animal studies have indicated that consumption of green tea and high vitamin E intake are associated with a reduced risk of developing certain forms of cancer. However, the inhibitory mechanism of green tea catechins and vitamin E in angiogenesis, an important process in tumor growth, has not been well established. In the present study, alpha-tocopherol and several major catechins of green tea (catechin, epicatechin, epicatechin gallate, epigallocatechin, and epigallocatechin gallate) were tested for their ability to inhibit tube formation in vitro using a model in which human microvascular endothelial cells were exposed to a constant rate of a physiologically low level of H2O2. In this model, the production of interleukin (IL)-8 by human microvascular endothelial cells at a low level of H2O2 was required for angiogenesis, as assessed by tube formation in three-dimensional gel in culture. Vitamin E (d-alpha-tocopherol, 40 microM) in the culture media significantly reduced IL-8 production and angiogenesis. Among the green tea catechins, epigallocatechin (0.5-1 microM) was the most effective in reducing IL-8 production and inhibiting angiogenesis. These results suggest that consumption of green tea catechins or supplemental intake of vitamin E may have preventive effects on tumor development, mediated, at least in part, through inhibition of angiogenesis via suppression of IL-8 production.
PMID: 12094614 [PubMed - indexed for MEDLINE]