Latest scoop on Melanotan II?

[YankeesRtheBest]

I wa sjust curious if anyone knew about that melanotan product that was discussed a while ago. Will this product actually become a reality and make rosaceans tan, giving them natural protection from the sun? Is there an approximate year that this may be released? 2006, 07 maybe? Thanks.
-Chris

[todmiller]

You can go to www.epitan.com.au and sign up to receive their updates.

I think this product will make it to the market. May not get US FDA approval for some time, but might still be "attainable" via the web, who knows. My guess is that in 4 years the Ausies will finish testing it.

However, there are reports of flushing from some who have undergone testing.

One positive thing to consider is that this flushing was reported with what might have been an initial high dosage. Perhaps the end product will require a smaller dose, which might not make people flush at all. (We'll find out eventually.)

However, a negative factor to consider is that somebody from marketing told me that their exclusion criteria included any skin conditions (including rosacea, I assume). In other words, those who flushed didn't even have rosacea. So who knows what it might do to rosaceans. I'm guessing they won't bother testing it on us, and we'll just have to find out for ourselves. Worth a shot, in my opinion. I look forward to this product as well. Heck, if nothing else it's an advancement in medicine of some sort. I love it when we figure out ways to fool mother nature! =)

[drnase]

You can go to www.epitan.com.au and sign up to receive their updates.

I think this product will make it to the market. May not get US FDA approval for some time, but might still be "attainable" via the web, who knows. My guess is that in 4 years the Ausies will finish testing it.

However, there are reports of flushing from some who have undergone testing.

One positive thing to consider is that this flushing was reported with what might have been an initial high dosage. Perhaps the end product will require a smaller dose, which might not make people flush at all. (We'll find out eventually.)

However, a negative factor to consider is that somebody from marketing told me that their exclusion criteria included any skin conditions (including rosacea, I assume). In other words, those who flushed didn't even have rosacea. So who knows what it might do to rosaceans. I'm guessing they won't bother testing it on us, and we'll just have to find out for ourselves. Worth a shot, in my opinion. I look forward to this product as well. Heck, if nothing else it's an advancement in medicine of some sort. I love it when we figure out ways to fool mother nature! =)


Todd,

I also have hope for this product. They actually started out with the goal of making it an indication for people prone to skin cancer and photo-sensitive dermatoses. We shall see what they eventually decide.

Good point on the doseage -- they have changed that and it will come in several doses. The tanning effects occur so quickly and last so long that one should not need a large bolus of the drug to make a marked difference on rosacea skin. This would even out the blotchiness, be a pretty darn good concealer for rosacea redness and make rosacea skin much less reactive to sun and external heat.

[YankeesRtheBest]

Thanks man, I appreciate the reply. Yea, I knew I should have gotten my hopes up. It's such an up and down roller coaster with this thing. Thanks again though. -Chris

[drnase]

Thanks man, I appreciate the reply. Yea, I knew I should have gotten my hopes up. It's such an up and down roller coaster with this thing. Thanks again though. -Chris


I think the biggest concern right now is with males (spontaneous errections). I hope this was not too blunt. :shock:

[QSilverTwo]

If anyone is interested in finding out more about this drug, head on over to www.melanotan.org where there is tons of info and self research results.

[Mermaid]

You can go to www.epitan.com.au and sign up to receive their updates.

I think this product will make it to the market. May not get US FDA approval for some time, but might still be "attainable" via the web, who knows. My guess is that in 4 years the Ausies will finish testing it.

However, there are reports of flushing from some who have undergone testing.

One positive thing to consider is that this flushing was reported with what might have been an initial high dosage. Perhaps the end product will require a smaller dose, which might not make people flush at all. (We'll find out eventually.)

However, a negative factor to consider is that somebody from marketing told me that their exclusion criteria included any skin conditions (including rosacea, I assume). In other words, those who flushed didn't even have rosacea. So who knows what it might do to rosaceans. I'm guessing they won't bother testing it on us, and we'll just have to find out for ourselves. Worth a shot, in my opinion. I look forward to this product as well. Heck, if nothing else it's an advancement in medicine of some sort. I love it when we figure out ways to fool mother nature! =)


Todd,

I also have hope for this product. They actually started out with the goal of making it an indication for people prone to skin cancer and photo-sensitive dermatoses. We shall see what they eventually decide.

Good point on the doseage -- they have changed that and it will come in several doses. The tanning effects occur so quickly and last so long that one should not need a large bolus of the drug to make a marked difference on rosacea skin. This would even out the blotchiness, be a pretty darn good concealer for rosacea redness and make rosacea skin much less reactive to sun and external heat.

Hi Geoffrey,

This will probably come out sounding really naive and obvious but is it possible to get all those benefits you mentioned without getting a tan?

I like my pale skin and am probably in the vast minority who doesn't desire a tan.

I'm guessing that I'll be waiting for some other innovation.

Thanks Geoffrey,

Mermaid

[Kris Jacobs]

Spontaneous erections? Really?

I know that when Epitan first started testing Melanotan, the medicine worked/stayed in the body for about a month. Initially this was a concern because flushing for a month straight could be devastating to rosacea sufferers. And the worst part is that there is nothing we could do about it.

From what I understand now, the new trials have given positive results because they can control how much of this enters the blood stream.
Could be promising.

Kris jacobs

[irishgenes]

Mermaid, I have pale white skin and red hair, too, and have never tanned well. I freckle, so I think Epitan would just make me freckle. I think we would be well protected from sun flushing with Glisodin, and it is available right now. In fact, I just ordered some last night. (See thread on Glisodin Supplement in the Oral Products, Non-prescription.) http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=12074&zoneid=23

[fanta]

I doubt GliSodin has some actions against skin cancer, but perhaps it will reduce sun-induced inflammation a little bit (probably not that much for rosaceans with VEGF out of order).

[Mermaid]

Mermaid, I have pale white skin and red hair, too, and have never tanned well. I freckle, so I think Epitan would just make me freckle. I think we would be well protected from sun flushing with Glisodin, and it is available right now. In fact, I just ordered some last night. (See thread on Glisodin Supplement in the Oral Products, Non-prescription.) http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=12074&zoneid=23

Hello Irish....

Thank you so much for the link. I will be ordering this supplement pronto!

I'd also like to thank you for being there for all of us, with your advice, intelligence and compassion. It is greatly appreciated and although many do not tell you, they will be thinking it.

Mermaid

[francois]

I wonder whether melatonan makes people flush only once right after it is injected or taken or do you flush frequently all those months until its effects disappear. That must be horrible.

[fanta]

I wonder whether melatonan makes people flush only once right after it is injected or taken or do you flush frequently all those months until its effects disappear. That must be horrible. NOT ONLY WILL YOU FLUSH ALL THOSE MONTHS, PLEASE BE CAREFUL! :^o

[Max]

I wonder whether melatonan makes people flush only once right after it is injected or taken or do you flush frequently all those months until its effects disappear. That must be horrible.

all those that reported flushing was short term, sounds similar to a niacin...

QSilverTwo already posted melanotan link, here's a direct link to the forum:
http://melanotan.org/cgi-bin/yabb/YaBB.pl

[Max]

I wonder whether melatonan makes people flush only once right after it is injected or taken or do you flush frequently all those months until its effects disappear. That must be horrible. NOT ONLY WILL YOU FLUSH ALL THOSE MONTHS, PLEASE BE CAREFUL! :^o

what makes you think that flushing will last that long? doesn't that stuff have a half-life period as all other things? i don't buy it :)

some pics of "beta-testers":

http://melanotan.org/cgi-bin/yabb/YaBB.pl?board=melanotan2exp;action=display;num=112 7398813

http://melanotan.org/cgi-bin/yabb/YaBB.pl?board=melanotan2exp;action=display;num=112 4584787;start=39

quite impressive... and maybe too much :)

[fanta]

All this is BS, dont trust the photos, they have been made up. You are not allowed to provide that kind of photos publically if you were indeed part of any melanotan studies.

[francois]

Is it colour blindness or those men look red after being injected? :shock:

[fanta]

The site is nonsense, dont trust everything on the internet, the guy had a sun burn, accutane affected his pigmentation thats :-({|=

[yossarian]

The site is nonsense, dont trust everything on the internet, the guy had a sun burn, accutane affected his pigmentation thats :-({|=

I'll take your advice and completely ignore you.

[fanta]

The site is nonsense, dont trust everything on the internet, the guy had a sun burn, accutane affected his pigmentation thats :-({|=

I'll take your advice and completely ignore you.
Yoss, I wont tolerate such a tone! [-X

[Max]

All this is BS, dont trust the photos, they have been made up. You are not allowed to provide that kind of photos publically if you were indeed part of any melanotan studies.

they are getting that stuff directly and are not part of any study, they are just freaks trying to get tanned.

[Max]

Is it colour blindness or those men look red after being injected? :shock:

one has go a "healthy glow" - really looks bit like rosacea - look at his chin...

[mikey]

How would they be getting it directly?

[fanta]

How would they be getting it directly? ummm umm uuu :-#

[QSilverTwo]

It's a synthetic peptide which can be made by most any lab with experience. There are sources in the buying and selling section of the melanotan.org site just to let you know. But it's not something to be takin lightly as it costs about 500 dollars just for one cycle. So only to those who are really white and have never tanned before is it worth the investment. This guy had a very successful run of the stuff, look http://melanotan.org/cgi-bin/yabb/YaBB.pl?board=melanotan2exp;action=display;num=112 3174464;start=30#30

[drnase]

All the people involved in the original testing at U of Arizona think this will work. Their main focus was on skin cancer and inflammatory skin disorders like lupus and sunsensitive disorders, so I wonder why some are saying this is contraindicated. The only contraindication that I can see is for males to go to the nude beach while taking this medication. Probably would not need any stands for your beach umbrellas. :shock:

[todmiller]

Fanta,

I appreciate your skepticism. I don't know whether to believe the pics myself. But I can tell you from my own experience in participating in a clinical trial that there are no rules against posting pics yourself or telling others how the trials is going for your or anything else. No rules regarding confidentiality whatsoever.

I thought there would be, too. But there weren't, there aren't. Maybe things are different in Australia, but if the rules are not different, these guys are not breaking any rules whatseover by showing these pics during the clinical trial.

Your assumption makes sense, but for some reason it's not the case. Probably because they know people will talk regardless, and they need their participation to push their product through the clinical trial process, so they don't even bother with any sort of confidentiality agreement.

That said, I will also remaing skeptical about melanotan until it actually hits the store shelves.

[irishgenes]

QSilverTwo, the picture on the link you posted of Spencer--I notice that his tan stops a bit short of his hairline. Now, if he had a tanning spray on his face, they probably have him use a shower cap, and that is the result he would get. If it were the Melanotan, the tan would blend imperceptably into the hairline. So this is a clue to me that he really wasn't using the Melanotan. Also, in his white skin photos, you see he has big freckles. I don't think Melanotan could give someone who freckles like that an even tan, because it can't change the way a red haired person's melanocytes respond to sun, can it?

[fanta]

no one believes those pics, you cant produce this substance easily, its derived by microbiologists at University of Arizona and the dude on the pic did not exactly look like someone with connections to a university lab

[QSilverTwo]

Obviously, Irishgenes, you're not as white as Spencer was or as I was and fail to realize there is no spray on tan or fake tanner in existence that can get us that dark and natural looking. I don't know if you saw the pictures on the other pages of his post or not but if you did you would have noticed that on his chest area there are vague white dots where for some reason he doesn't have as much melanin. This is another indication of why it would be impossible for a spray on tan to achieve this look. And lastly, there is no logical reason for him to show fake results. There is no incentive for him to do so whatsoever. He is not a supplier of the peptide, doesn't advertise for anyone who does so, and has no association with epitan. The melanotan board is just the same as this one. It's a place for people with a condition to go and communicate with one another. It's exactly like rosacea, in that if you don't have the disease (white, almost albino like skin that never tans) then it is relatively impossible for you to understand our motives for using a drug that is, at this point, still unapproved by the FDA.

Anyway, it is only natural to be skeptic with a drug claiming something as bold as melanotan does. But if you just take the time to absorb the info the forum has to offer you and educate yourself and not remain ignorant, then you would see the authenticity of it all. That's up to you though, I really don't care (no offense).

[QSilverTwo]

Oh, and about there being a "tan line" around Spencer's hairline. Uh, that is pretty natural. I don't know why you would assume that is a spray on tan. In fact, a spray on tan would produce an even more obvious line and not as gradual. The sun cannot penetrate through hair so I don't know why you think he should be tan there. Maybe you don't realize that even with melanotan in your system it only stimulates melanocyte production. To get a tanning effect you have to do what anyone else does and that is to receive some sort of UV exposure.

[fanta]

Oh, and about there being a "tan line" around Spencer's hairline. Uh, that is pretty natural. I don't know why you would assume that is a spray on tan. In fact, a spray on tan would produce an even more obvious line and not as gradual. :-({|=


To get a tanning effect you have to do what anyone else does and that is to receive some sort of UV exposure.
Ah =; Not true! read more about it, you get increased pigmentation without sun light, but sun light enhances the effect :^o

[QSilverTwo]

Well, you can believe that. I know that's what they claim on the epitan site, and that may infact be true with the final implant version, but I know from experience it does nothing to affect skin color without any UV. Although I am type I or less naturally and it might be people with type III or IV skin see color enhancement without UV.

The point is, to get any descent noticable color you have to expose yourself to UV and epitan does hint towards this actually. Without UV you will still see darkening of moles and have increased tolerance to burning.

No one who has experimented, including myself, has seen any real noticable color improvements without UV exposure.

[irishgenes]

Oh, and about there being a "tan line" around Spencer's hairline. Uh, that is pretty natural. I don't know why you would assume that is a spray on tan. In fact, a spray on tan would produce an even more obvious line and not as gradual. The sun cannot penetrate through hair so I don't know why you think he should be tan there. I know that you don't tan through hair, but it looked to me like the tan stopped short about 1/2" of the hairline. I am as white as Spencer was, but I have never had a spray-on tan as I have never desired a tan. I'm perfectly happy to have lily white skin. I've seen formerly pale-skinned celebrities with spray-on tans that looked the same as Spencer's, so I don't think I'd agree that you can't get a natural-looking tan with them.

But I did not mean to offend you--didn't realize that you were part of the Melanotan forum. By all means, carry on with your tanning if it makes you happy. Now that I see the white areas on his back, I would say that Spencer's tan is probably due to Melanotan. I just wonder how the drug can change the melanocytes in the skin from their usual freckling to even tanning.

[QSilverTwo]

Irishgenes, no offense taken, maybe I was a bit too defensive. Spencer could have quite possibly gotten a haircut too or had his bangs combed down while in the tanning bed. Just be aware he has no reason to lie. If you could read through his every post you would see he is a very genuine, honest person. With that said, there are a few photos from other people that look suspicious, but again, I don't see why they would falsify their results if it has no benefit to them. Melanotan hasn't worked for everyone though. Two people have reported no tanning effect at all. That's out of quite a few however, so it seems the drug has a high success rate. I'm glad you are so happy with your skin. I wish I could feel the same way, but regardless I am happy now and that's all that matters.

[irishgenes]

I'm glad you are so happy with your skin. I wish I could feel the same way, but regardless I am happy now and that's all that matters. Well, I wouldn't say that I am happy with my skin! I'm not happy with my wrinkles and the occasional p&p of rosacea. (I don't have the permanent redness of rosacea yet.) But I am satisfied with the color that God gave me. To me, a healthy young-looking skin is beautiful, whether it is black, brown, or white. I guess men have more of a need to appear tanned, as it gives one that rugged outdoorsy look. Women of my generation in the southern US tried to avoid sun so that we wouldn't look aged before our time. Unfortunately, I spent every summer from age 7 to 17 at the beach in Florida and got quite a few sunburns. We kids used to think it was such fun to pull large sheets of skin off each others' backs! There was no such thing as sunscreen, and my skin shows the damage today.

[QSilverTwo]

Yeah, I would have to say being a guy with white skin is not a good situation. Especially with accompanying moles, freckles, kp bumps, and not to mention rosacea. I would much rather be a girl as your half seems to have just better, more attractive, and even toned skin. Now with a tan all I need is a drug similar to melanotan that will eliminate my annoying red cheeks and prohibit any flushing. God, I seem so vain complaining about all this superficial stuff. I guess I just can't help how it affects me. Oh well.

[fanta]

What if you flush from melanotan? then you would look purple, is this what you want? :-s

[QSilverTwo]

COOL!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! :roll:

[Bob Bear]

I dont know what to think about this treatment at present. I shall wait until it is released, then discuss it with my doc. If it looks promising, then I wont hesitate to give it a try.

Right now, its all 'ifs' and 'buts'. Lets wait for something concrete before we make a decision :wink: