potential replacement of certain antibiotics

[hope]

scientists have already created an nanobiotic agent that can decrease the ability for bacteria to adapt and thereby grow resistant to the drug like they would with conventianal antibiotics. of course this will have positive implications for anyone considering long term antibiotic use in the future.

http://www.foresight.org/nanodot/?p=2016

[drnase]

scientists have already created an nanobiotic agent that can decrease the ability for bacteria to adapt and thereby grow resistant to the drug like they would with conventianal antibiotics. of course this will have positive implications for anyone considering long term antibiotic use in the future.

http://www.foresight.org/nanodot/?p=2016


Thanks Hope. Good news. I am extremely excited by the chemical modification of antibiotics that some pharmaceutical companies are performing -- not sure exactly how they are doing it but they are now removing all antibiotic actions at all doses and enhancing their anti-inflammatory actions for skin disorders and arthritis/degenerative disorders of blood vessels and cartilage.

[YankeesRtheBest]

1.) Will it be the same antibiotics, just enhanced? For instance, will doxycycline still be called doxycycline, but will it be a new kind that doesn't deal with the bacteria and only have enhanced anti-inflammatory actions?

2.) When will these new antibiotics be available?

[prryjones]

Hi all,
This is interesting stuff.
It's not too hard to understand tweaking the molecule to limit/eliminate bacteriocidal/static effect, but I can honestly say that in 4 yrs of pharmacy school...I've never seen addressed exactly how certain antibiotics exibit anti-inflammatory effects (other than killing the bugs which cause the inflammation).
I will certainly ask this question the next time I speak with an infectious disease expert, and post his response.
Perry

[drnase]

Hi all,
This is interesting stuff.
It's not too hard to understand tweaking the molecule to limit/eliminate bacteriocidal/static effect, but I can honestly say that in 4 yrs of pharmacy school...I've never seen addressed exactly how certain antibiotics exibit anti-inflammatory effects (other than killing the bugs which cause the inflammation).
I will certainly ask this question the next time I speak with an infectious disease expert, and post his response.
Perry


Good to see you back Perry,

It is my understanding that normal antibiotics have an anti-inflammatory action by decreasing neutrophil migration and also interfering with the arachidonic acid cascade.

The new antibiotics being modified have additional qualities -- decrease nitric oxide (inducible), VEGF and cell adhesion molecules.

[prryjones]

Thank you, Geoff.
I'm certainly glad to see you're still with us, as well. :D
Perry

[Bob Bear]

Did someone say Nitric Oxide. Perry, I think thats our que... :lol:

Geoffrey, is this what is going on down at Collagenex?

[drnase]

Did someone say Nitric Oxide. Perry, I think thats our que... :lol:

Geoffrey, is this what is going on down at Collagenex?



Bob,

Are you and Perry going to ravage another thread? :D Yep. That's what collagenex is doing. Dr. Theobald is a mad scientist/physician who is cutting and cleaving to enhance the anti-inflammatory actions and also increase the dose substantially with little side effect. Some versions totally normalize inducible nitric oxide in animal models with inflammatory skin disorders that they induce. When you think of inducible nitric oxide you should think of triggered or activated nitric oxide in response to the inflammatory condition. Then two things happen:

1. Inducible nitric oxide sythase produces gobs of nitric oxide, a potent dilator.

2. Nitric oxide in high concentrations binds with a superoxide anion and forms peroxynitrate, the single most damaging oxidant known to medicine -- it chews up blood vessel walls and dermal architecture.

[prryjones]

Hi Dr. Nase and Bob,
Dr. Nase, I appreciate your cluing me in on doxycyclines' potential role in inhibiting collagenase activity (in vitro, anyway). (You know in school we learn mostly the traditional indications for these drugs).
Anyway, after reviewing Periostat, have found the molecule is identical to doxy. Exactly. And doxy, unlike the prior tetracyclines, is very acid stable and lipophillic, hence the long t1/2. Could easily sit in liquid form on a shelf for a week without degrading.
Anyway...you know how cheap I am and how disdainful I am of pharmaceutical companies selling less drug for more money (another classic example is Propecia), I have Doxy 100's on the way. I will find a suitable solvent and therefore one can split the Doxy 100 into 5 doses (Periostat is 20mg/dose). Hide from light, take on an empty stomach if possible and thus should cost less than a dollar per week to possibly help keep the skin from thinning.
Question is, I think AB use had been linked to intracranial pressure if taken concommitently with Acutane (it's never bothered me, but I have a big head, anyway), so don't know if 20mg qd would affect this or not.
Any thoughts on this?
Perry
ps Bob...I did not mention NO....no...not even ONCE in this reply.....

[drnase]

Hi Dr. Nase and Bob,
Dr. Nase, I appreciate your cluing me in on doxycyclines' potential role in inhibiting collagenase activity (in vitro, anyway). (You know in school we learn mostly the traditional indications for these drugs).
Anyway, after reviewing Periostat, have found the molecule is identical to doxy. Exactly. And doxy, unlike the prior tetracyclines, is very acid stable and lipophillic, hence the long t1/2. Could easily sit in liquid form on a shelf for a week without degrading.
Anyway...you know how cheap I am and how disdainful I am of pharmaceutical companies selling less drug for more money (another classic example is Propecia), I have Doxy 100's on the way. I will find a suitable solvent and therefore one can split the Doxy 100 into 5 doses (Periostat is 20mg/dose). Hide from light, take on an empty stomach if possible and thus should cost less than a dollar per week to possibly help keep the skin from thinning.
Question is, I think AB use had been linked to intracranial pressure if taken concommitently with Acutane (it's never bothered me, but I have a big head, anyway), so don't know if 20mg qd would affect this or not.
Any thoughts on this?
Perry
ps Bob...I did not mention NO....no...not even ONCE in this reply.....


Hi Perry,

That is right, Periostat was not modified. They just lowered the dose to a level where it had not bacteriostatic actions. They have shown in vito though a very strong anti-collagenase and anti-elastase action on skin and gums. It halts or slows down gum disease.

I think since you are a resident pharmacist (at least very soon) that you could do what you will with the larger doses to save money.

I really should not comment on the intracranial pressure here. Please PM me.