Sneak Peak at Upcoming Dermatology Times Article

[drnase]

Group,

I am submitting a link for a sneak peak at the upcoming article:

New Hope for Rosacea: Treating Facial Redness, Flushing and Triggers

Now, I must warn you that they wanted to put it in qutie badly because it was cutting edge info. -- but they had very limited space (approximately 500 words). The coolest stuff is down at the bottom, but it would have taken 10 pages each to expain them, so I was forced to just condense them and address them each one at a time in upcoming successive articles. Here is the sneak peak.

http://www.drnase.com/DermatologyTimesArticle.htm

Regards,

Geoffrey
__________________________________

Dr. Geoffrey Nase
Ph.D. Neuro-Vascular Physiologist
Rosacea Research Specialist & Consultant
http://www.drnase.com
______________________________

[Bob Bear]

Kelli,

I think he means that P&P is an end result of the underlying symptoms. Get them and you get ALL the superficial ones too. Kind of like is you had the worst migranes ever - you could take about 75 asprins a day, or you could try to get the route of the problem.

Believe me, I dont think anyone here would under estimates the misery of rosacea!

[drnase]

Honestly, Dr. Nase - this ticks me off:

For several decades physicians have focused on treating superficial symptoms of rosacea such as papules and pustules.

They aren't superficial! They f'ing hurt! They're disgusting.

I know you had flushing, but did you have any of the P&P? The huge cysts that cause shooting pain that reaches your toes if you barely brush it by accident?

Hi Kelley,

This was meant for the dermatologists -- they know they have been focusing on just papules and pustules. Your cysts are not superficial. They are deep and extremely painful. The length limitation only allowed me to focus the one article on flushing and triggers. Actually the dapsone should be theoreticlally able to pentrate farther and have much better actions against your cysts. So, hopefully I did cover that to some extent. Remember I only had 500 words to sqyeese into a spot and they enlarged it to 750 for me.

[Bob Bear]

Its a great article Dr Nase - gives people like myself a renewed sense of hope. Especially the last one, these sounds like they could spell the end of rosacea for most sufferers.

[Kelli]

What I'm meaning is the wording of it. By stating that they are superficial, it's confirming to Dr.s that everyone thinks they are. Superficial in my book means insignificant. That they aren't a big problem to deal with.

If they don't even know if rosacea is completely vascular or if there is a place in there where it could be something else, why trivialize symptoms?

[Tricia]

Wow, this is truly fantastic stuff! You've mentioned in the past that good things were on the horizon but I never imagined this good............quite encouraging!

Tricia

[Kris Jacobs]

I am speechless........
but truly thankful for you Dr. Nase!

[jane]

What great news! I am totally happy. I just hope everything works out. Thank you so much Dr. Nase. I have been suffering with 100 degree temps and having to stay indoors all the time, my skin is always reactive, I am recooperating from a bad IPL treatment with someone that didnt know what they were doing, I have been getting tiny little hard circular bumps in my flush zones that look a little like freckles, but a hard nodules, and I have no idea what they are. All this stuff was needed for me years ago. Please let it work. Incidentally, if you know what the bumps are, please clue me in. My doctor says it might be like cholasma, but this is usually just a flat, pigmented condition. I'm very worried that it is secondary to all of the IPL treatments, and I pray to God that it is not related to the flushing. Thanks again.

[jane]

What great news! I am totally happy. I just hope everything works out. Thank you so much Dr. Nase. I have been suffering with 100 degree temps and having to stay indoors all the time, my skin is always reactive, I am recooperating from a bad IPL treatment with someone that didnt know what they were doing, I have been getting tiny little hard circular bumps in my flush zones that look a little like freckles, but a hard nodules, and I have no idea what they are. All this stuff was needed for me years ago. Please let it work. Incidentally, if you know what the bumps are, please clue me in. My doctor says it might be like cholasma, but this is usually just a flat, pigmented condition. I'm very worried that it is secondary to all of the IPL treatments, and I pray to God that it is not related to the flushing. Thanks again.

[todmiller]

Thank you for the article. However,

2. Atrix Laboratories proprietary Solvent Microparticle (SMP TM ) delivery system is specially formulated to deliver highly insoluble drugs through the skin in a non-irritating, time-released fashion. This technology is truly changing the way we approach rosacea treatment because most medications that could help treat rosacea redness and flushing have been sitting on shelves because they were insoluble and thus could not be used. The SMP TM technology first delivers an unencapsulated drug followed by encapsulated microparticles of the drug, providing delayed release of agents into the dermal tissue for sustained 24 hour treatment.

How can I put this? ... I don't believe you!!! =) Next you're going to tell me they're putting men on the moon! =)

How can a topical deliver in a time-delayed fashion?

And would we have to avoid washing our faces? Not that I do that much anyway, at least not at work.

Thank you.

[drnase]

Thank you for the article. However,

2. Atrix Laboratories proprietary Solvent Microparticle (SMP TM ) delivery system is specially formulated to deliver highly insoluble drugs through the skin in a non-irritating, time-released fashion. This technology is truly changing the way we approach rosacea treatment because most medications that could help treat rosacea redness and flushing have been sitting on shelves because they were insoluble and thus could not be used. The SMP TM technology first delivers an unencapsulated drug followed by encapsulated microparticles of the drug, providing delayed release of agents into the dermal tissue for sustained 24 hour treatment.

How can I put this? ... I don't believe you!!! =) Next you're going to tell me they're putting men on the moon! =)

How can a topical deliver in a time-delayed fashion?

And would we have to avoid washing our faces? Not that I do that much anyway, at least not at work.

Thank you.

Thats OK Todd, I would not believe it myself, but the technology is finally there and they have verified this via independent laboratories via measurements every few hours. While they wont release the exact technology, it most likely has to do with encapsulation in various pouches of various thickness that release in response to heat or other factors -- so the thinner ones break open more quickly and the thicker ones take much longer to break open and release the drug. I have read quite a lot about all the new liposomes and carrier molecules and youre jaw would drop at what they can do now. I do know that it has been verified to release its last portion 21 to 22 hours after topical application.

Excellent question and thanks for the faith bro!

[drnase]

What I'm meaning is the wording of it. By stating that they are superficial, it's confirming to Dr.s that everyone thinks they are. Superficial in my book means insignificant. That they aren't a big problem to deal with.

If they don't even know if rosacea is completely vascular or if there is a place in there where it could be something else, why trivialize symptoms?


Kelli,

You know me. I would never trivialize any part of rosacea. If is at the heart a vascular disorder -- those cysts are formed primarily through angiogenesis, wrapped up vessels, etc. Normalize the vessels and the cysts go away and even if they dont, you would now be able to use topicals to clear them up that you were never able to use in the past because the blood vessels are now under control and normally reactive.

[drnase]

Todd,

Missed your last sentence.

After 1 hour you could wash your face and swim, etc. because it is inside the dermis and not laying on the stratum corneum.

[Tamara]

Dr. Nase,

These new developments sound phenomenal and it's awesome that you have managed to find a way to quickly begin to get this information out to all derms in America. You will educate them even if they learn while kicking and screaming, won't you?

How did things turn around so fast? It's hard to believe. Just a short time ago it all looked so dismal, it seemed that no decent research was being done and no hope was on the horizon. Now here we are about to receive a wealth of possibilties. It's such a relief to have hope. Thanks for keeping us informed and hoping. Will these developments decrease or eliminate the need for IPL/laser treatment?

Again, Thanks for All You DO! You're Amazing.

Tamara

[drnase]

Dr. Nase,

These new developments sound phenomenal and it's awesome that you have managed to find a way to quickly begin to get this information out to all derms in America. You will educate them even if they learn while kicking and screaming, won't you?

How did things turn around so fast? It's hard to believe. Just a short time ago it all looked so dismal, it seemed that no decent research was being done and no hope was on the horizon. Now here we are about to receive a wealth of possibilties. It's such a relief to have hope. Thanks for keeping us informed and hoping. Will these developments decrease or eliminate the need for IPL/laser treatment?

Again, Thanks for All You DO! You're Amazing.

Tamara


Hello Tamara,

Thank you. It may seem like these are just popping up, but people forget that things dont get officially announced for a couple years into testing.

Remember I predicted these exact products 13 to 15 months ago based on research into these different companies. I called the series, New Hope and Advances around the Corner, but everyone seems to have forgotten. That is why it is great to have some inside guys -- not only for true hope but for brief examples (all that I could legally say at the time). Remember, in my book I forecasted over a dozen topicla and oral meds 4 years in advace that have come to fruition and still more coming. There are 4 more products in the initital phases that I will soon give information out when I get the official OK from the companies.

To be honest, they finally started listening to us and my articles and contacted me to see what was needed. That is the truth and I told them what they were all missing and they then approached it with their own unique ways.

The biologic response modifiers are going to be our cures and near cures. Only those who have sustained decades of vascular damage will need to get laser first to reverse this, but then never again.

The next two biologic response modifiers will be irreversible lock and key treatments which mean they fit into an enzyme and alter its abnormal behavior, but is locked in their permanently, so only one treatment.

There is also a series of superficial, non painful shots that will inject other biologic responose modifiers to change neural activity locally in a permant fashion-- these automatic multipronged injections are almost completely devoid of pain and can cover large areas of facial skin quickly. Probably one to three treatments and done. Move on with life. Sit is a hot car, relax dont turn on the ac and keep the windows rolled up while your passenger is flushing and sweating. Real stuff. Wont that be a hoot. Wake up in the morning with a pale face, go too work wiith a pale face, forget about dodging any triggers, and go home at night with a pale, comfortable face with no burning or stinging.

[Tamara]

Dr. Nase Said: Won't that be a hoot.
It will indeed be a hoot. I'm ready for it. The more you tell the more incredible it sounds.

Tamara

[Lars]

I can't say that I understand this. But it's some new treatments - right?
:oops:

Some that will be available in the near future - how near?
And not only in America? :?

[Bob Bear]

I remember those threads you posted (just over a year ago). Believe me, I can see that you knew about this stuff long ago. And I am SOOO happy that we are growing ever nearer.

[Bob Bear]

Dr. Nase Said: Won't that be a hoot.
It will indeed be a hoot. I'm ready for it. The more you tell the more incredible it sounds.

Tamara

Indeed it will guys, indeed it will. The thought that I could sit outside the pub and have a quick half after work on a nice summers day... that would mean the world to me right now. Just to be able to occassionally savour lifes little pleasures would be amazing.

[Bob Bear]

Please excuse me if I'm a bit reluctant to believe all of this. Especially with my issues with the wording to begin with.

In another thread, we're talking about ways to bring rosacea and the pain that goes along with it to the forefront of physicians mind's. Then the next thing they see is a researcher calling parts of it superficial. How are we supposed to get our Dr.s to understand the severity of it if parts are being trivialized? I keep saying that, because that is how it still looks. YOU may know it's not trivial to have cysts, and P&P, but THEY don't. WE rely on you to tell them for us.

Kelli, honestly I think you are taking the word superficial out of context. I believe superficial is a term the docs use for a certain type of symptom - not the same meaning that you or I would use in everyday life. I think you're symptoms, no matter how horrible, are in medicine described a superficial. Im sure everyone who reads that article knows full well that these symptoms are anything but superficial in real world speak.

Please, correct me if Im wrong here.

[Kelli]

Then they need to change it. Just like their thinking of rosacea.

I would compare this to people saying that "rosacea is just a minor inconvenience. People just blush a little bit."

[Bob Bear]

Edited for incorrect info,

BB

[prryjones]

Kelly, the word, superficial, in medical terminology means "towards the surface"...such as describing facial redness as superficial redness...occurs at the "top" of the skin (right under the epidermis). It describes location. The opposite is "deep".

Hi Geoffrey,
I believe you mentioned a 3 to 5 year likely timeframe for the Sansrosa product making it to market. Regarding the earlier potentials mentioned (and maybe some that you couldn't mention), what is a realistic (conservative) time frame for some/any of these experimental drugs getting to market? I know this is impossible to tell, as all the unforseen variables...but possibly something in the next 10 years?
Thanks,
Perry

[drnase]

Then they need to change it. Just like their thinking of rosacea.

I would compare this to people saying that "rosacea is just a minor inconvenience. People just blush a little bit."


Kelli,

Superficial means at the top of the skin -- where papules and pustules are and very superficial redness occurs.

The heart lies in the mid dermis vasculature and nerves. These are not medically called superficial.

Kelli, I can only do so much. Sincerely, the heart of rosacea has never ever been addressed at all, so it is clearly time to discuss this one subject a few times. The last two decades they have been focusing on the superficial symptoms AND I did add topical dapsone which should be excellent for superficial symptoms.

[drnase]

Kelly, the word, superficial, in medical terminology means "towards the surface"...such as describing facial redness as superficial redness...occurs at the "top" of the skin (right under the epidermis). It describes location. The opposite is "deep".

Hi Geoffrey,
I believe you mentioned a 3 to 5 year likely timeframe for the Sansrosa product making it to market. Regarding the earlier potentials mentioned (and maybe some that you couldn't mention), what is a realistic (conservative) time frame for some/any of these experimental drugs getting to market? I know this is impossible to tell, as all the unforseen variables...but possibly something in the next 10 years?
Thanks,
Perry


Perry,

The thing that saves us is that the first three have already passed FDA approval for human treatment of some form, so I would expect them out in 2.5 to 3 years at the very most. I need to hear more about the biologic modifiers to even begin to guess.

[clsykes00]

Dr Nase,

Great information and well contructed executive summary of the leading promising future treatments.

As someone who likes suggestions to refine my work, I was wondering if a more interesting lead in to this would be a paragraph with the theme of "new treatments that will help those suffering lead a more normal life - tx XYZ has promise of allowing suffers to exercise more routinely, etc., Without these promising treatments, Rosacea suffers will still be essentially handicapped by their afflication." You know the tenor and climate of among dermatologist and insurance companies better than I do, but I wonder if further emphasizing that rosacea is not just a cosmetic issue will further propel momentum towards a deeper understanding of the real issues here. Could be an opportunity to match a) the need with b) the products/treatments and most importantly for dermatologist to start getting a real handle on the issues around resolving rosacea.

I think you have done an exceptional job and can't thank you enough Dr. Nase.

All the best,
Trey

[PeaceFroggy]

Dr. Nase,

Will the SansRosa product be effective for those of us who may have developed rosacea as a complication or side effect from other treatments or diseases (as opposed to it having a genetic origin)? How about the biological response modifiers?

Thanks

[ihaterosacea]

First of all, God bless you, Dr. Nase, for giving us a new hope. :D

Do you know if the new treatments could also be used on necks, arms and hands as well? Ever since I developed rosacea, these other areas are starting to flush and lately have stayed pink permanently.

Thank you!
Annie

[Tricia]

I assume these companies are conducting or are going to be conducting clinical trials for their products. How do we sign up??? Dr. Nase do you think you could pass along The Forum website so they could post when they are in need of guinea pigs? What better source to tap into for a variety of suffers?

Tricia

[drnase]

I assume these companies are conducting or are going to be conducting clinical trials for their products. How do we sign up??? Dr. Nase do you think you could pass along The Forum website so they could post when they are in need of guinea pigs? What better source to tap into for a variety of suffers?

Tricia

I wish Tricia, but doctors dont want to join unmoderated groups like this one and Dr. Crouch has recently bowed out because of attacks.

[DrD]

dr. Nase, Is there any way that I can get hold of the original source documentation from which the summaries were extracted?

thx

[adyus]

I've just read the article on derm. times. Congratulations for your very good article, Dr.Nase.

Best wishes,

Adrian Constantin

[DukeCity]

Two years later and still waiting... hope springs eternal.

[Millie]

Waiting for what??? Quarterly reports? Blogs? Patents? Creams? Wands?

Phew.... that' a lot of waiting!

[tkr]

millie how is your skin?? tamara the z cream??

[DukeCity]

Millie,
I was mainly thinking of the SansRosa we've been waiting for..