Keep an eye out for the upcoming Aug 1 Derm Times Issue

[drnase]

Hi Group,

I am submitting an article on four new treatments that address facial redness, flushing and trigger reduction in the upcoming Derm. Times August issue. These are the first meds to ever address the facial redness, flushing and many of the triggers. It is quite complex, so I would be happy to discuss these one at a time once the issue is in print.

I will be discussing the latest findings on the SansRosa product, the oral blocker of iNOS & VEGF and two revolutionary topicals that directly attack rosacea and put the beast back in its corner -- selective topical vascular smooth muscle Kinase activators and selective topical G-protein uncouplers.

[NoMoreRed!]

I think... I think I love you, Geoffrey. :)

Is it possible to read the article on the Internet in August? Is it a Derm. Times-website or something? I'm in Norway. :(

[drnase]

Great PM question from the ESFB Board.

Yes, the G-protein uncouplers will be available topically. You could never give this orally anyway. The drug(s) fit into the lock and key portion of the G-Protein and uncouple the G-Protein. This stops the "Dilate" signal from dozens of different neural, humoral, mechanical and endothelial signals.

The key here is that some of these Biotechs and medium size Pharmaceutical companies are HUNGRY and have figured out the smart way to approach this. It is very possible that we may have 75 to a 100 different mechanisms that cause dilation. Therefore we would need 75 to a 100 different blockers to stop the flush and trigger.

But, the farther down the pathway you go and address it a the vascular smooth muscle layer -- many of these mechanisms funnel into one or two pathways. Block them there!

[drnase]

I think... I think I love you, Geoffrey. :)

Is it possible to read the article on the Internet in August? Is it a Derm. Times-website or something? I'm in Norway. :(


Thanks. I need to get to know you better first.

The physical articles are mailed out Aug. 1. Then there is a two to three week delay before they post it on their Internet site for free. DermatologyTimes.com I think.

[drnase]

I think... I think I love you, Geoffrey. :)

Is it possible to read the article on the Internet in August? Is it a Derm. Times-website or something? I'm in Norway. :(

Nomorered,

You can follow this link to it once it is out.

http://tinyurl.com/8scb5

[drnase]

Yes,

The kinase enzymes will be selectively activated via topical transdermal delivery systems that do not disrupt the epidermis.

[jane]

Have any of these transdermal delivery systems been tried out with any of the substances we have been talking about? For example, to anyone's knowldge, has botox ben tried out in this way? What were the outcomes if any?

[drnase]

Have any of these transdermal delivery systems been tried out with any of the substances we have been talking about? For example, to anyone's knowldge, has botox ben tried out in this way? What were the outcomes if any?


Jane,

Good question. Yes, they have been tested out (I dont know about Botox though) with transdermal delivery systems like Restoraderm. For example, Restoraderm® is a unique and patented dermal drug delivery system. Formulated with lipids normally found in the skin, Restoraderm® offers rapid penetration and absorption into the stratum corneum. Once passing through this external layer of the skin, Restoraderm® delivers active ingredients to the dermal layers underlying the skin barrier. This patented technology provides a physiologic vehicle base that is readily accepted into the dermis.

In contrast to Restoraderm®, other formulations which are used to enhance penetration through the skin typically employ mechanisms that disrupt the normal barrier with concomitant physiological consequences. Restoraderm® is formulated to enhance penetration while leaving the normal barrier intact or even functionally enhanced. This effect is achieved by careful selection of the lipids of the vehicle, which blend with the normal lipids present in the stratum corneum, resulting in a temporary and reversible disruption and enhanced penetration, followed by a rapid return to normal barrier function. Additionally, Restoraderm's patented formulation offers superior cosmetic elegance. This feature promotes patient compliance and greater therapeutic success.

[Jonesy]

Dr Nase, do these journals/articles spread beytond the US? Being from the UK and having experienced much of the ignorance that surrounds rosacea amongst practitioners, I really hope that articles like yours will be read by pracitioners over here and might bring rosacea more to the forefront of the minds of practitioners. Having recently been told that I can't have rosacea 'because you don't have spots' (having previously been told by another doctor that I was too young at 19), I am concerned about the lack of knowledge of 'experts' over here! I hope they are going to be privvy to the same cutting edge information as their US colleagues.

[Bob Bear]

Jonesy,

Are you sure you're not one of my alter-egos? Because what you just explained is like the mirror of my own experiences! Here's a few quote for you:


"Sorry son, you cant have rosacea, you're not a middle aged white woman"

"You dont have rosacea, you're nose looks perfectly normal"

"Rosacea is a facial rash, flushing has nothing to do with it"


Forget about hoping, lets pray that these guys get proper info. Cuz without our Dr's on side, we dont really stand a dog in hells chance.

[Jonesy]

LOL. The nose quote there is unbelievable. Absolutely shocking..... The one who told me I was too young laughed as he said it (I asked him about rosacea rather than him bringing it up) as if to say 'you moron, of course you haven't got rosacea'.

The other guy who said it couldn't be rosacea 'because I didn't have spots'........ I was just absolutely aghast. That was literally a few days ago, and armed with the knowledge I have from this board, I know it couldn't be more wrong...... :evil:

What makes me most angry is that I am suffering today, July 2005, because of ignorance. Simple as that. :(

[Bob Bear]

Yep, it is a shame that we have to resort to using the internet for our medical advice. We are lucky that people like Dr Nase are around to assist us in making treatment decisions.

I can tell you for a fact that without Dr Nases book and advice, I would not have gotten the right treatment.

[jane]

I agree Dr. Nase is wonderful! If Restoraderm is already available, could it be trialed with something like Botox? How is it in terms of the sensitivity on rosacea skin?
I want to be as diplomatic as I can here, so here goes: Dr. Nase, hypothetically speaking, if I were to get an approval for this to be trialed by an experienced dermatologist, that I believe you know, would you have access to the equipment and/or a desire to test this with him? I don't want to leave Botox alone because it has worked so well for me in the past. Although still having major problems, the area treated over 3 years ago is still aparent.

[prryjones]

Hi Dr. Nase,
Hope everything is well as can for you be at this point!
I love hearing good news like this. It seems that SOMEONE in industry has figured out the possible market value of any anti redness/flushing meds.
I am curious. Since many (most?) MD's think rosacea is cured, or at least can be adequately tx'd with the current regimens (eg metronidazole)...and since rosacea (still) doesn't get the recognition it deserves....WHO (eg NRS)? is the impetus behind all this R&D? (I mean...I wish we had some sort of lobby, etc...a "voice"...but we dont.
Or...have they just finally figured out that there is money to be made here, and once a product is on the market, the response from the "silent" millions will respond?
Do the developers conduct market surveys and polls to determine whether a drug has profit potential?
Respectfully,
Perry "I feel good!" Jones

[Bob Bear]

Perry,

Is it possible that much of the research is conducted for similar vascular disorders, yet applies equally to rosacea? This is what I always figured.

Lets hope that we can rise the profile of rosacea enough to put it on the map. I have to say, Im surprised this hasnt already happened - everyone knows someone who blushes or flushes. Girls in particular notice these kind of things (Im blessed with two sisters!). There seems to be a cream for everything these days, so it only makes sense that antiredness / flushing treatments should be on the agenda.

But it looks like we're gradually floating in the right direction. Lets hope this article gives us a sterdy push! Congrats Dr Nase.

[drnase]

Hi Dr. Nase,
Hope everything is well as can for you be at this point!
I love hearing good news like this. It seems that SOMEONE in industry has figured out the possible market value of any anti redness/flushing meds.
I am curious. Since many (most?) MD's think rosacea is cured, or at least can be adequately tx'd with the current regimens (eg metronidazole)...and since rosacea (still) doesn't get the recognition it deserves....WHO (eg NRS)? is the impetus behind all this R&D? (I mean...I wish we had some sort of lobby, etc...a "voice"...but we dont.
Or...have they just finally figured out that there is money to be made here, and once a product is on the market, the response from the "silent" millions will respond?
Do the developers conduct market surveys and polls to determine whether a drug has profit potential?
Respectfully,
Perry "I feel good!" Jones


The doctors finally figured out that all the other inflammatory skin disorder where genetic based and all of them involve flushing or skin dilation to some extent. So, it was not rosacea that pushed the envelope, it was the other disorders.

[drnase]

I agree Dr. Nase is wonderful! If Restoraderm is already available, could it be trialed with something like Botox? How is it in terms of the sensitivity on rosacea skin?
I want to be as diplomatic as I can here, so here goes: Dr. Nase, hypothetically speaking, if I were to get an approval for this to be trialed by an experienced dermatologist, that I believe you know, would you have access to the equipment and/or a desire to test this with him? I don't want to leave Botox alone because it has worked so well for me in the past. Although still having major problems, the area treated over 3 years ago is still aparent.


Ironically, it is going through its last approval to market -- it is being held back because you cannot have ceramides in a prescription medication. Absolute quote from their department. But, it should be just a short time.
The Restoraderm is a low lather foam that goes on great and feels wonderful on the skin. We would fist need to find out how well Restoraderm goes with BOTOX. Atrix SMP may be a better carrier.