Oral Nitric Oxide Synthase Inhibitor for Rosacea

[drnase]

Group,

An oral medication that blocks inducible nitric oxide in rosacea sufferers is finally in the mix. It has shown excellent results in preliminary clinical studies and now is entering the final phase I studies on a large group of erythematotelangiectatic rosacea sufferers (officially phase Ic).

Inducible nitric oxide synthase is shown to be significantly increased in active rosacea skin and nonexistent on parts of the face that show no signs of rosacea. This medication nomalizes iNOS activity to that of non-rosacea skin and the vascular symptoms show excellent clearance except for telangiectasia. Very intriguing. Only real side effect reported in a small percentage is increased photosensitivity.

Regards,

Geoffrey
__________________________________

Dr. Geoffrey Nase
Ph.D. Neuro-Vascular Physiologist
Rosacea Research Specialist & Consultant
http://www.drnase.com
______________________________

[Bihbicat]

Well, this sounds exciting. Do you have any idea what the medication is actually derived from? Also, is there any indication of possible toxicity for the liver assuming it's one of those meds that gets worked through the liver? Perhaps that the kind of thing that takes awhile to show up yes? With my liver issues I tend to shy away from medications unless absolutely necessary, which means I dream of a non-oral, topical or laser/IPL type cure, but hey, if it works and doesn't put too much strain on the old girl I'd certainly consider it.

[prryjones]

Hi,
Way too early to be concerned with the adverse effects profile of this 'potential' new drug. How about let see if it works first and makes it to market?
Second, many "comprehensive" ADR profiles (incl. hepatotoxicity) aren't recognized till after the drug has been used in the general population for some time (it has to be used my many before these side effects come to light). An excellent example is the recent news with the NSAIDS (rofecoxib/Vioxx) and the current issues with the statin drugs concerning myotoxicity (muscle damage). Both had been out for years before these potentially life threatening ADRs surfaced. That's just the way it goes.
Perry
ps not that anyone asked, but I'd damn sure trade my liver for 5 years of living like a normal human being (again).

[IowaDavid]

w00t!

We sign me up for any human trials they need.... :D

[drnase]

Well, this sounds exciting. Do you have any idea what the medication is actually derived from? Also, is there any indication of possible toxicity for the liver assuming it's one of those meds that gets worked through the liver? Perhaps that the kind of thing that takes awhile to show up yes? With my liver issues I tend to shy away from medications unless absolutely necessary, which means I dream of a non-oral, topical or laser/IPL type cure, but hey, if it works and doesn't put too much strain on the old girl I'd certainly consider it.

Sorry, but on the run. It is a modified new macrolide that has been chemically altered to treat skin cancer (major iNOS involvement), but as perry said, way too soon to predict side effects other than a couple clincial studies showing very good efficacy. Great starting point. I would have given up my liver also for five years -- Bihi, we can all chip in and get you a new one on the black market.......or from Perry while he is sleeping.

[prryjones]

Hi Dr. Nase,
I'll keep my liver...but you can have my freckles, thanks.
Perry
ps You don't want my liver anyway...tried the DF fluconazole 'cure' and ruined it...thanks DAVE.
ps2...can't see either....

[drnase]

Hi Dr. Nase,
I'll keep my liver...but you can have my freckles, thanks.
Perry
ps You don't want my liver anyway...tried the DF fluconazole 'cure' and ruined it...thanks DAVE.
ps2...can't see either....


Perry ---PLEASE, PLEASE, PLEASE, PLEASE TELL ME YOU DID NOT TRY THE DAVE FLEMMING DMSO FLUC. CURE. PLEASE. DID IT NOT WORK? SHAME ON YOU. Of all the people.

[prryjones]

Hi Dr. Nase,
Sure...it worked...Dave said it would, didn't he???
I just hang around rosacea forums b/c I like to argue.
Perry
ps gotta go now...can't see the screen anymore...vision going.....

[drnase]

Hi Dr. Nase,
Sure...it worked...Dave said it would, didn't he???
I just hang around rosacea forums b/c I like to argue.
Perry
ps gotta go now...can't see the screen anymore...vision going.....


We need to take a break from each other. I cant even imagine how many brain cells were firing when you slathered that flesh eating DMSO on.

Did your liver function return to normal yet? Its a pretty resiliant little organ.

[prryjones]

Dr. Nase,
I was just kidding about the DMSO (and poking a little fun at DF at the same time). Havent heard much about the ridiculous 'cure' lately, which is good.
Perry
ps I'm not aware that either DMSO or fluconcazole cause hepatic ADRs anyway....

[Bob Bear]

Funnily enough a guy was talking about it on ESFB just the other day. Its amazing how this info gets around. I think most will smell a rat when they read the word 'cure' in the description, but for the unfortunate few who get suckered it must be terrible.

Thank god we have places like this where we can be informed of such products. Who knows, had it not been for Dr Nase I may have used this stuff myself :shock:


Also, yes very exciting about this new drug. There are so many mild subtype I sufferers who could benefit from this (as we seem to be growing in numbers). Lets hope that it lives up to our expectations, and becomes a recognised rosacea treatment.

[Bihbicat]

Well Perry, all I can say is if you feel you'd trade your liver so readily and that my concern about the toxicity of drugs is premature you must not be living with a potentially fatal liver disease as I am. Try it sometime -- it sure puts rosacea into perspective.

[drnase]

Well Perry, all I can say is if you feel you'd trade your liver so readily and that my concern about the toxicity of drugs is premature you must not be living with a potentially fatal liver disease as I am. Try it sometime -- it sure puts rosacea into perspective.


Bihi,

We were both kidding around. I am so sorry to hear this. Is it treatable without transplantation? Do any of the natural supplements to boost liver health, liver enzyme activity and cytochrome P450 pathways help?

[prryjones]

Bihi,
There was no reason to take my response personally.
I was not criticizing your concern, only stating the fact that many times (actually most) of the time the complete effects profiles of drugs aren't known until the drug has been passed through 3 phases of clinical trials and is used by the population. This makes sense. Compared to the relatively few humans exposed to drugs during clinical trials, the whole human population is bound to expose aspects of the drug than were revealed in the controlled studies.
The 'premature' statement wasn't referring to your concern, but simply meant that such aspects of these drugs aren't known yet, at this point in their development.
Perry

[prryjones]

Bihi,
Oh...by the way...I now realize that this is the 'Ask Dr. Nase' forum, and so I should not have responded to your comments, anyway. I just forgot which forum I was in, I guess.
Apologies to both you and Dr. Nase for speaking out of turn.
Sincerely,
Perry

[Bihbicat]

No worries Perry. I did understand the point you were making re: it taking time for toxicity to be known -- I acknowledged that probability in my original post. I was just wondering if the drug came from some already known source the toxicity of which was already somewhat understood, or a completely new source that nothing is known about.

And don't worry Dr Nase, your fooling around was fine. As to your question re: my condition -- there is a sort of cure but it's one of those ones that is worse than the disease -- I tried it and it kicked my butt bad and I had to come off. I'm not at the stage where I need a transplant and dearly hope I never reach that point. From what can be told from bloodwork (which doesn't give a complete and full picture as you know) my healthy lifestyle and high doses of Milk Thistle and ALA etc do seem to be helping keep things under control to some degree, though without a nasty biopsy (and I'm not keen to have another if I can help it) there's no knowing for sure.

Anyways, it just means I'm less enthusiastic about drug cures because most of them would put a big strain on my liver, which means I fantasise about some magic machine or topical appearing overnight that will stop rosacea in its tracks. Yeah right!

[drnase]

Bihi,
Oh...by the way...I now realize that this is the 'Ask Dr. Nase' forum, and so I should not have responded to your comments, anyway. I just forgot which forum I was in, I guess.
Apologies to both you and Dr. Nase for speaking out of turn.
Sincerely,
Perry


Hey Perry -- anyone can respond to any question........ except for those that tried the Flem Cure. So, you are out, but everyone is more than welcome to put their two cents in. Just not Perry. Dont ever hesitate to post on this subforum. Except Perry. Its a group thing (minus Perry).

[todmiller]

Maybe this topic should be spawned in a separate thread, but this one is a good segue...

Other than having to wait for long-term public use of a medicication to answer the side effect question, the other potential obstacle is politics and $money$. I heard a rumor that the health problems posed by vioxx were known by the big cats of the manufacturer, but that he "was thinking about his family and career" in his decision to hide this data.

Now I read that there are many investigations into trials that research that may have been "doctored". =)

Any thoughts on this? I certainly WANT to believe that the vast majority of studies report TRUE findings. I can live with a 50/50 chance that a medication won't work for me. But please don't tell me it will work for me, knowing instead that it will induce a heart attack in my mid-30s!!!

[prryjones]

Thanks Bihi.

Wow...I haven't heard the word, "dufus" in at least 20 years!
Dr. Nase...you're getting old!
Signed,
Perry "DMSO will have you smelling like a rotten turnip" Jones

[drnase]

Bihi,
Oh...by the way...I now realize that this is the 'Ask Dr. Nase' forum, and so I should not have responded to your comments, anyway. I just forgot which forum I was in, I guess.
Apologies to both you and Dr. Nase for speaking out of turn.
Sincerely,
Perry


Hey Perry -- anyone can respond to any question........ except for those that tried the Flem Cure. So, you are out, but everyone is more than welcome to put their two cents in. Just not Perry. Dont ever hesitate to post on this subforum. Except Perry. Its a group thing (minus Perry).


Perry, I am not old! I would never ever use the term dufus because it is corny and outdated. I dont see it in my edited quote above.

[Bob Bear]

Geoffrey and Perry,

With that kind of language I shall start calling you Bill and Ted. :lol:

[drnase]

Geoffrey and Perry,

With that kind of language I shall start calling you Bill and Ted. :lol:


Perry did get the best of me. I did say dufus, but I love the ability to edit your own comments days after you make mention of outdated words like that.

[Bob Bear]

God bless the internet. :wink:

[prryjones]

Dr. Nase,
HA! And I thought it was all that DMSO making me hallucinate....
Perry

[muzzle]

Anyone care to explain about this DMSO/fluconazole (sp?) business? It's going *swoosh* over my head..

[Bob Bear]

Hi Muzzle,

Im sure if you start a new thread Dr Nase and/or someone else will fill you in on all the details.

Im not a Dr and have very little knowledge of such things. However, I got the jist that DMSO is very dangerous stuff to be using on rosacea skin. Basically, dont touch it with a ten foot barge pool! Some guy called Dave Flemming was pushing on his website, claiming it was the cure wonder drug for rosacea sufferers.

[prryjones]

Hi muzzle,
Since I started the DMSO conversation, I'll fill you in. Dr. Nase may want to add to this.
A few years ago a layman (not a healthcare practicioner) advertised on the web that the combination of DMSO (a byproduct of the wood industry) and fluconazole (anti-fungal) completely cured his rosacea. He was very agressive and attracted much attention with his claims, attacking those who doubted him. No studies, evidence, etc. that his claim had a shred of truth to it (he wouldn't even post before and after pics of himself).

Unless studies later prove otherwise, it's considered completely bogus...voodoo by all (except by the one individual touting it).
DMSO, which is an antioxidant (free radical scavenger) and can be used as a skin penetration enhancer for certain drugs, can also cause corneal thinning. This has been proven in the lab.
I experimented with it orally (to the endless delight of Dr. Nase) and it made me smell awful and made my eyes burn.
Most would advise against using it for any medicinal purpose.

Perry "Dr. Nase-is-gonna-let-me-have-it-for-sure-this-time" Jones

[IowaDavid]

Let's not forget Flemming's bulletin board site. Was it, "Rosacea-Cure"? Or "Rosacea-Truth"? I emailed back and forth with him about the matter and then he started going on tirades about drug company conspiracies holding back rosacea treatment and the evil designs of the "white coats."

Yeah, I think I'd give his approach a shot. He's a beautiful orator. ;)

[drnase]

P-E-R-R-Y. I am sorry, but as moderator of this subforum, I must take action. It is my duty. You are officially on a three minute time out. No posts by you for three minutes. Hopefully you will learn from this. Next time it will be four minutes and I dont want to go there.

[Bob Bear]

Perry,

Come join us in the garden of banishment! Here the food is always cold, and it never stops raining (kind of like Stafford, haha).

[prryjones]

Hi Bear....yep, it's lonely out here in deep space...just me and Marc....

[Bob Bear]

Perry,

You are not alone, I too have recently joined the ranks, lol. Maybe we need a support forum - I'll moderate and if anyone kicks up a stick, well you know what'll happen. :lol:

[drnase]

Bob and Perry -- Do you really want to take it to the next level? Think carefully before you answer this one. And no LOL while you are in time out.

[Bob Bear]

Dr Nase,

I just wanted to say that none of this was my idea, its was all Perry's fault, he made me say it.

I think he should get Trump style 'You're Fired'.

[drnase]

Dr Nase,

I just wanted to say that none of this was my idea, its was all Perry's fault, he made me say it.

I think he should get Trump style 'You're Fired'.



Perry and Bob.... Bob and Perry. You are the first two to officially make my list. Number one and two.

For all of those wanting to read more about nitric oxide blockers, I apologize for the delay and we will get right back to it.

For all of those wathcing the Perry and Bob show, I am sorry to say, but the show was cancelled due to poor writing and terrible actors. We will immediately resume with the Simpsons.

[Bob Bear]

Christmas card list, wow thanks!


Sorry, Nitric Oxide it is!

So Dr Nase, it seems that there are several treatments on the horizon all targetting very different thing (please correct me if this is inaccurate). With Sansrosa, VEGF, Kinase, NO... is it likely we'll need a cupboard full of creams and pills to keep the dreaded beastie at bay? Or do some of these cross over?

Seriously, I find this stuff so interesting. I dont understand the nuts and bolts or it, but i can ususally get the jist.

I see you have done a far few papers on NO, have you found out much since the release of your book?

[prryjones]

Dr Nase,

I just wanted to say that none of this was my idea, its was all Perry's fault, he made me say it.

I think he should get Trump style 'You're Fired'.

Thanks Bob! (boy...with friends like this....)!

[Bob Bear]

Perry,

Honestly mate, it wasnt my fault. Dr Nase made me blame it on you.

Actually I probably shouldnt say that, dont want the 'men in black' using it as fodder!

[prryjones]

Perry,

Honestly mate, it wasnt my fault. Dr Nase made me blame it on you.
!

Gee whiz, Bob!
I bet if you were a country during WW2 (or 1), then you'd be Italy!!! :mrgreen:
(no offense Dr. Nase...ooops...Geoffrey)....
Perry

[Bob Bear]

Perry,

Im sorry man, I couldnt help it, the Nazi's made me do it! :lol:

[drnase]

Dear Bob and Perry,

I would like you to apologize publicly to all the dear folks who came here to read about nitric oxide inhibitors.

For all the mothers out there with young immature bratty children, how many time outs are you suppose to give your kids before you smack them upside the head?

[Bob Bear]

Dear Rosaceans,

I would like to publicly apologize for Perry's behaviour during this thread. It wasnt big, clever or professional. This is a rosacea board, and there is no place for this tom-foolary.

Regards,

BB

(Ok, I probably deserve a smack now :cry: )

[muzzle]

Three is good.

[Bob Bear]

Ok, Im officially out of smart arse comments.

Rosacea anyone? I hear that Nitric Oxide is great stuff...

[Kris Jacobs]

It's great to see a little comic relief. Thanks guys
And Dr. Nase......
I am speechless
nos inhibitors and sanrosa etc sound very promising. and the dermatology article you are wrting in August will put us back in the race for a cure!!!!!
thank you
Kris Jacobs