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drnase
21st June 2005, 10:27 AM
They have already isolated and blocked the modifier gene for VEGF topically in psoriasis patients.



Detmar, M. (2004) Evidence for vascular endothelial growth factor (VEGF) as a modifier gene in psoriasis. J Invest Dermatol 122, xiv-xv

yossarian
21st June 2005, 09:25 PM
What exactly can be done for genes? If a gene is blocked topically, well, what exactly does this mean for the gene and the disease it causes? To what extent and what duration does this blocking treatment work?

drnase
22nd June 2005, 04:51 AM
Its a cure. A gene is turned into a protein such as a receptor or a part of a blood vessel wall, etc. You can very selectivley find the abnormal gene(s) and block them from ever being turned into a 'bad rosacea protein'. This results in permanent changes.

todmiller
22nd June 2005, 06:37 AM
Is this strictly preventative, or could it also reverse damage already done?

Also, great post. And the references in Beating Rosacea are excellent as well. But what is the best way to look up the references for the full scoop? Is there an online website that has them in a database or something?

Thank you.

22nd June 2005, 07:30 AM
So is psoriasis now considered cured?

drnase
22nd June 2005, 08:03 AM
This would address the number one cause of plaque psoriasis. It would eliminate the symptoms and you possibly may need a treatment every couple years to sustain remission. There are other forms of psoriasis that are caused by various factors.

I found this out just through researching medical journals -- the old fashioned way. Actually opening them up. No key board required. I am sure they have many psoriasis information groups.

drnase
22nd June 2005, 08:08 AM
So is psoriasis now considered cured?


Not quite yet Sally.

yossarian
22nd June 2005, 10:38 AM
The future sounds hopeful. How far away are these treatments?