cox 2 inhibitors?

[prryjones]

Hello all,

Bingo Bango! Dr. Nase, I guess this one if for you... :D
Any thoughts on controlled use of the cox 2 inhibitors to augment IPL tx?
As you know, some work has been done regarding Celebrex's role as an AI....
Thanks,
Perry
ps topical preparations have been made in the lab, so apparently can go through the skin. Inflamed rosacea skin, especially post IPL trauma, would probably increase the permeability.

[granola grrrl]

Hi there Perry!

Very interesting. I am also always interested in natural alternatives to AI and remember reading that Green Tea is a cox 2 inhibitor and AI inhibitor too (I think). Read a bit more on it today at this link
http://www.greenteahaus.com/group-i.htm

Do you know if these green tea creams and sunscreens could be benefiting this pathway (i.e. could they absorb to that level?). Just wondering if it would be a good post-IPL topical IF it had any AI activity???

Also wondering what phase in study topical AI inhibitors are at these days. Dr. Nase was mentioning that shark cartilage has not got quite there yet in its application for AI for things like rosacea.

Interested in your scientific take on this.

Nice to see you:)
Shelley

[prryjones]

Hi Shelley,
It's really nice to hear from you.
Angiogenesis inhibitors are really a hot topic today, mainly due to their implications on tumor growth. Dr. Nase, with the inside info., I think has mentioned that release of any topicals for our purposes are years away.
Anyway, so I'm always on the lookout for some formulation already on the market that, as it turns out, displays AI properties. Celebrex is one (prob. other cox 2 inhibitors also, but most research has been done with Celebrex). Aldara (for genital warts) is another. Aldara is sold as a topical, Celebrex is not, but has been used as a topical in research, proving that the molecule can penetrate human skin.
(BTW, I have a script for Aldara...will keep the forum updated on the progress once I begin using it).
The active ingredient (molecule in the medicine which makes it work) in Celebrex is rather small and somewhat lipophillic, making is suitable to pass through the main barrier against topical drug absorbtion --the stratum corneum. Also, the face is the best area of the body, aside from the genitals, in absorbing a topical drug. Add an IPL tx on top of already inflamed rosacea skin (traumatized skin absorbs better than non), and I think that mixing the contents of a celebrex cap with a suitable penetration enhancer may provide significant absorbtion. Of course one could also simply take it oral post IPL, except that some that would be squeamish due to the recent cardiovascular implications of the Cox 2's.
There were a no. of studies in phase 1 and 2 clinical trials concerning Celebrex's role in tumor growth inhibition ( I think some have since been cancelled), so the data is pretty convincing (I saw a recent -May 05- study on Medline recently). Anyway...I'm rambling.....here is a good link summarizing AI's....you may find it interesting...its nice to read that the market is becoming aware of the potential profits from this 'technology'...as this will certainly fuel awareness and R&D in this area.
Take care,
Perry
http://www.mindbranch.com/products/R294-0146_executive.html